NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

Intestinal epithelial cells (IECs) form a critical barrier against pathogen invasion. By generation of mice in which inflammasome expression is restricted to IECs, we describe a coordinated epithelium-intrinsic inflammasome response in vivo. This response was sufficient to protect against Salmonella...

Full description

Saved in:

Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 46; no. 4; pp. 649 - 659
Main Authors:	Rauch, Isabella, Deets, Katherine A., Ji, Daisy X., von Moltke, Jakob, Tenthorey, Jeannette L., Lee, Angus Y., Philip, Naomi H., Ayres, Janelle S., Brodsky, Igor E., Gronert, Karsten, Vance, Russell E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 18-04-2017 Elsevier Limited
Subjects:	Animals Apoptosis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism ASC Bacterial infections Bone marrow Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Caspase 1 - genetics Caspase 1 - metabolism Caspase 8 - genetics Caspase 8 - metabolism Caspase-1 Caspase-8 Cytokines Eicosanoids - metabolism Enzyme Activation Enzyme-Linked Immunosorbent Assay Epithelial Cells - metabolism Epithelial Cells - microbiology Epithelium Expulsion extrusion Immunology Infections inflammasome Inflammasomes Inflammasomes - genetics Inflammasomes - metabolism Inflammation Interleukin-18 - metabolism intestinal epithelial cell Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intracellular Signaling Peptides and Proteins Ligands Lipids Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Microscopy, Confocal Mutation Naip Neuronal Apoptosis-Inhibitory Protein - metabolism Nlrc4 Organoids Pathology Phosphate-Binding Proteins Rodents Salmonella Salmonella Infections - metabolism Salmonella Infections - microbiology Salmonella typhimurium - physiology Small intestine Studies Caspase-8 ASC intestinal epithelial cell inflammasome extrusion Nlrc4 expulsion Naip Caspase-1
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!