Effects of perinatal dioxin exposure on mirror neuron activity in 9-year-old children living in a hot spot of dioxin contamination in Vietnam

• Published in: Neuropsychologia Vol. 161; p. 108001
• Main Authors: Vu, Hoa Thi, Nishijo, Muneko, Pham, Thao Ngoc, Pham-The, Tai, Hoanh, Luong Van, Tran, Anh Hai, Tran, Nghi Ngoc, Nishino, Yoshikazu, Do, Quyet, Nishijo, Hisao
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 15-10-2021
• Subjects: Brain development; Dioxin; EEG power; Mirror neuron system; Vietnam; Vietnam; EEG power; Mirror neuron system; Dioxin; Brain development
• ISSN: 0028-3932; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2021.108001

For 8 years, we have followed up a birth cohort comprising 241 mother-and-infant pairs living around the Da Nang airbase, a hot spot of dioxin contamination in Vietnam, and have reported the impacts of perinatal dioxin exposure on the neurodevelopment of children at various ages. In the present study, 9 years after birth, we investigated the effects of perinatal dioxin exposure on mu and theta rhythms by analyzing EEG power during the execution and observation of hand movements, which indicate mirror neuron system activity.
One hundred fifty-five 9-year-old children (86 boys and 69 girls) from the Da Nang birth cohort participated in the EEG examination with free viewing of hand movements. The dioxin levels in their mothers’ breast milk, measured 1 month after birth, were used as perinatal dioxin exposure markers. A log transform of the ratio of EEG power during execution or observation of the hand movements relative to the power during observation of a bouncing ball for theta and mu rhythms was used to evaluate mirror neuron activity.
In both brain hemispheres, the log power ratio in the theta band was significantly higher (i.e., less reduction of power) during observation of hand movements in girls exposed to high levels of TCDD. In boys, however, dioxin congeners other than TCDD, including HxCDDs and several PCDF congeners, contributed to increased log power ratios in the theta band. Particularly for PCDF congeners, the log power ratios in the lowest group among 4 exposure groups were lowest and significantly increased (i.e., decreasing reduction of power) with increasing dose.
Perinatal TCDD exposure may influence the mirror neuron system of the brain, which plays an important role for social-emotional behavior in children, particularly in girls living in a hot spot of dioxin contamination in Vietnam.
[Display omitted]
•Perinatal TCDD exposure decreased mirror neuron activity in 9-year-old girls.•Increasing some PCDF congeners significantly decreased mirror neuron activity in boys.•Mirror neuron impairment may be involved in developmental deficits due to dioxin exposure.