Polyphenol-rich açaí seed extract exhibits reno-protective and anti-fibrotic activities in renal tubular cells and mice with kidney failure

Polyphenol-rich açaí seed extract exhibits reno-protective and anti-fibrotic activities in renal tubular cells and mice with kidney failure

The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure was induced chemically with an adenine-rich diet (0.25% w/w for 4 weeks) in male CD1 Swiss mice. Mice were then provided daily with ASE (at a...

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Published in:Scientific reports Vol. 12; no. 1; p. 20855
Main Authors: Monteiro, Elisa Bernardes, Borges, Natalia Alvarenga, Monteiro, Mariana, de Castro Resende, Ângela, Daleprane, Julio Beltrame, Soulage, Christophe Olivier
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 02-12-2022
Nature Publishing Group
Nature Portfolio
Subjects:
631/1647/334/1874/345
631/443/272
692/4022
692/4022/1585/104
692/4022/1585/3182
Adenine
Animals
Antioxidants
Antioxidants - pharmacology
Atrophy
Collagen
Drinking water
Fibrosis
Gelatinase
Humanities and Social Sciences
Humans
Kidney
Kidneys
Leukocytes (neutrophilic)
Lipocalin
Male
Mice
multidisciplinary
Phenolic compounds
Phenols
Plant Extracts - pharmacology
Polyphenols - pharmacology
Proteinuria
Renal failure
Renal function
Renal Insufficiency
Science
Science (multidisciplinary)
Toxins
Transforming Growth Factor beta1 - genetics
Transforming growth factor-b1
Uremia
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Abstract The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure was induced chemically with an adenine-rich diet (0.25% w/w for 4 weeks) in male CD1 Swiss mice. Mice were then provided daily with ASE (at a dose of ~ 350 mg/kg/day) in drinking water for 4 weeks. Adenine mice exhibited renal dysfunction evidenced by increased proteinuria, increased uremia, extensive tubular atrophy and kidney fibrosis associated with overexpression of pro-fibrotic genes (collagen 1a1, transforming growth factor β1, TGF-β1) and markers of tubular injury (such as Kidney injury molecule-1, KIM-1). ASE was able to beneficially counteract all these effects. ASE improved oxidative damage and fibrosis by decreasing carbonylated protein and MDA concentrations, as well as collagen deposition in renal tissue. ASE decreased the expression of TGF-β1 gene and the abundance of protein TGF-β1 in kidneys. It further decreased both expression and urinary excretion of tubular injury biomarkers, e.g., KIM-1 and Neutrophil gelatinase-associated lipocalin. CKD ASE-treated mice exhibited higher polyphenol content and total antioxidant capacity compared to control mice. ASE further prevented the expression of profibrotic genes in HK2 human tubular cells exposed to uremic toxins. Taken together, these findings suggest that ASE exerted potent reno-protective and anti-fibrotic effects through its antioxidant activity and the modulation of the TGF-β1 pathway.
AbstractList The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure was induced chemically with an adenine-rich diet (0.25% w/w for 4 weeks) in male CD1 Swiss mice. Mice were then provided daily with ASE (at a dose of ~ 350 mg/kg/day) in drinking water for 4 weeks. Adenine mice exhibited renal dysfunction evidenced by increased proteinuria, increased uremia, extensive tubular atrophy and kidney fibrosis associated with overexpression of pro-fibrotic genes (collagen 1a1, transforming growth factor β1, TGF-β1) and markers of tubular injury (such as Kidney injury molecule-1, KIM-1). ASE was able to beneficially counteract all these effects. ASE improved oxidative damage and fibrosis by decreasing carbonylated protein and MDA concentrations, as well as collagen deposition in renal tissue. ASE decreased the expression of TGF-β1 gene and the abundance of protein TGF-β1 in kidneys. It further decreased both expression and urinary excretion of tubular injury biomarkers, e.g., KIM-1 and Neutrophil gelatinase-associated lipocalin. CKD ASE-treated mice exhibited higher polyphenol content and total antioxidant capacity compared to control mice. ASE further prevented the expression of profibrotic genes in HK2 human tubular cells exposed to uremic toxins. Taken together, these findings suggest that ASE exerted potent reno-protective and anti-fibrotic effects through its antioxidant activity and the modulation of the TGF-β1 pathway.
Abstract The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure was induced chemically with an adenine-rich diet (0.25% w/w for 4 weeks) in male CD1 Swiss mice. Mice were then provided daily with ASE (at a dose of ~ 350 mg/kg/day) in drinking water for 4 weeks. Adenine mice exhibited renal dysfunction evidenced by increased proteinuria, increased uremia, extensive tubular atrophy and kidney fibrosis associated with overexpression of pro-fibrotic genes (collagen 1a1, transforming growth factor β1, TGF-β1) and markers of tubular injury (such as Kidney injury molecule-1, KIM-1). ASE was able to beneficially counteract all these effects. ASE improved oxidative damage and fibrosis by decreasing carbonylated protein and MDA concentrations, as well as collagen deposition in renal tissue. ASE decreased the expression of TGF-β1 gene and the abundance of protein TGF-β1 in kidneys. It further decreased both expression and urinary excretion of tubular injury biomarkers, e.g., KIM-1 and Neutrophil gelatinase-associated lipocalin. CKD ASE-treated mice exhibited higher polyphenol content and total antioxidant capacity compared to control mice. ASE further prevented the expression of profibrotic genes in HK2 human tubular cells exposed to uremic toxins. Taken together, these findings suggest that ASE exerted potent reno-protective and anti-fibrotic effects through its antioxidant activity and the modulation of the TGF-β1 pathway.
The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure was induced chemically with an adenine-rich diet (0.25% w/w for 4 weeks) in male CD1 Swiss mice. Mice were then provided daily with ASE (at a dose of ~ 350 mg/kg/day) in drinking water for 4 weeks. Adenine mice exhibited renal dysfunction evidenced by increased proteinuria, increased uremia, extensive tubular atrophy and kidney fibrosis associated with overexpression of pro-fibrotic genes (collagen 1a1, transforming growth factor β1, TGF-β1) and markers of tubular injury (such as Kidney injury molecule-1, KIM-1). ASE was able to beneficially counteract all these effects. ASE improved oxidative damage and fibrosis by decreasing carbonylated protein and MDA concentrations, as well as collagen deposition in renal tissue. ASE decreased the expression of TGF-β1 gene and the abundance of protein TGF-β1 in kidneys. It further decreased both expression and urinary excretion of tubular injury biomarkers, e.g., KIM-1 and Neutrophil gelatinase-associated lipocalin. CKD ASE-treated mice exhibited higher polyphenol content and total antioxidant capacity compared to control mice. ASE further prevented the expression of profibrotic genes in HK2 human tubular cells exposed to uremic toxins. Taken together, these findings suggest that ASE exerted potent reno-protective and anti-fibrotic effects through its antioxidant activity and the modulation of the TGF-β1 pathway.
ArticleNumber 20855
Author Monteiro, Elisa Bernardes
Borges, Natalia Alvarenga
de Castro Resende, Ângela
Daleprane, Julio Beltrame
Monteiro, Mariana
Soulage, Christophe Olivier
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  givenname: Natalia Alvarenga
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  organization: Nutrition and Genomics Laboratory, Basic and Experimental Nutrition Department, Institute of Nutrition, Rio de Janeiro State University
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  givenname: Mariana
  surname: Monteiro
  fullname: Monteiro, Mariana
  organization: Laboratório de Alimentos Funcionais, Nutrition Institute, Federal University of Rio de Janeiro
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  givenname: Ângela
  surname: de Castro Resende
  fullname: de Castro Resende, Ângela
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  givenname: Christophe Olivier
  surname: Soulage
  fullname: Soulage, Christophe Olivier
  email: christophe.soulage@univ-lyon1.fr
  organization: CarMeN, UMR INSERM U.1060, INRAe U1397, INSA-Lyon, Université Claude Bernard Lyon 1
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36460743$$D View this record in MEDLINE/PubMed
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Snippet The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney failure...
Abstract The main goal of this study was to evaluate the reno-protective effects of a phenolic-rich Açaí seed extract (ASE) in mice with kidney failure. Kidney...
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SubjectTerms 631/1647/334/1874/345
631/443/272
692/4022
692/4022/1585/104
692/4022/1585/3182
Adenine
Animals
Antioxidants
Antioxidants - pharmacology
Atrophy
Collagen
Drinking water
Fibrosis
Gelatinase
Humanities and Social Sciences
Humans
Kidney
Kidneys
Leukocytes (neutrophilic)
Lipocalin
Male
Mice
multidisciplinary
Phenolic compounds
Phenols
Plant Extracts - pharmacology
Polyphenols - pharmacology
Proteinuria
Renal failure
Renal function
Renal Insufficiency
Science
Science (multidisciplinary)
Toxins
Transforming Growth Factor beta1 - genetics
Transforming growth factor-b1
Uremia
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Title Polyphenol-rich açaí seed extract exhibits reno-protective and anti-fibrotic activities in renal tubular cells and mice with kidney failure
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Volume 12
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