Sarcoidosis: a pediatric perspective

Childhood sarcoidosis is a rare multisystemic granulomatous disease of unknown etiology. The clinical presentation can vary greatly depending upon the organs involved. Two distinct forms of sarcoidosis exist in children. Older children usually present with a multisystem disease similar to the adult...

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Bibliographic Details
Published in:	Clinical pediatrics Vol. 37; no. 12; p. 707
Main Authors:	Shetty, A K, Gedalia, A
Format:	Journal Article
Language:	English
Published:	United States 01-12-1998
Subjects:	Adolescent Adult Age Factors Biopsy Child Child, Preschool Female Humans Incidence Male Prevalence Radiography, Thoracic Sarcoidosis - diagnostic imaging Sarcoidosis - epidemiology Sarcoidosis - pathology Sarcoidosis - therapy United States - epidemiology
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Summary:	Childhood sarcoidosis is a rare multisystemic granulomatous disease of unknown etiology. The clinical presentation can vary greatly depending upon the organs involved. Two distinct forms of sarcoidosis exist in children. Older children usually present with a multisystem disease similar to the adult manifestation, with frequent hilar lymphadenopathy and pulmonary infiltration. Early-onset childhood sarcoidosis is a unique form of the disease characterized by the triad of rash, uveitis, and arthritis in patients presenting before age 4 years. The diagnosis of sarcoidosis is confirmed by demonstrating a typical noncaseating granuloma on a biopsy specimen. The current therapy of choice for childhood sarcoidosis with multisystem involvement is corticosteroids. Methotrexate given orally in low doses is effective and safe and has steroid-sparing properties.
ISSN:	0009-9228
DOI:	10.1177/000992289803701201