Salvage Bacteriophage Therapy for a Chronic MRSA Prosthetic Joint Infection

• Published in: Antibiotics (Basel) Vol. 9; no. 5; p. 241
• Main Authors: Doub, James B, Ng, Vincent Y, Johnson, Aaron J, Slomka, Magdalena, Fackler, Joseph, Horne, Bri'Anna, Brownstein, Michael J, Henry, Matthew, Malagon, Francisco, Biswas, Biswajit
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01-05-2020; MDPI
• Subjects: Antibiotics; Arthritis; Bacteria; bacteriophage therapy; Bacteriophages; biofilm; Biofilms; Case Report; Case studies; Chronic infection; Complications and side effects; Dosage and administration; Drug resistance; Drug therapy; Fractures; Implants, Artificial; Intravenous administration; Joint diseases; medication induced hepatitis; Methicillin; methicillin resistance Staphylococcus aureus; Mortality; Patient outcomes; Phages; Prostheses; Prosthesis; prosthetic joint infection; Respiration; Staphylococcal infections; Staphylococcus infections; Surgery; Therapy; United States; United States > US; Baltimore Maryland; bacteriophage therapy; medication induced hepatitis; biofilm; methicillin resistance Staphylococcus aureus; prosthetic joint infection
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics9050241

This is a case of a 72 year old male with a chronic methicillin-resistant
prosthetic joint infection. After the third intravenous dose of bacteriophage therapy, an unusual, reversible transaminitis prompted stoppage of bacteriophage therapy. Nevertheless, treatment was successful and the patient's severe chronic infection was eradicated.