Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions
Telomeres are the end regions of linear chromosomes, and in normal somatic cells the lengths of telomeres shorten with successive cell divisions. Telomerase, a ribonucleoprotein enzyme, maintains the length of telomeres in immortal and germline cells. Although present in human fetal tissues, shortly...
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| Published in: | Journal of investigative dermatology Vol. 106; no. 4; pp. 759 - 765 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
Elsevier Inc
01-04-1996
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| Abstract | Telomeres are the end regions of linear chromosomes, and in normal somatic cells the lengths of telomeres shorten with successive cell divisions. Telomerase, a ribonucleoprotein enzyme, maintains the length of telomeres in immortal and germline cells. Although present in human fetal tissues, shortly after birth telomerase activity is not detectable except in germline cells, hematopoietic cells, and most human primary tumors. In the present study we show telomerase activity to be present in 73 of 77 basal cell carcinomas, 15 of 18 nonmetastatic cutaneous squamous cell carcinomas, and 6 of 7 cutaneous melanomas, contrasting with extremely low levels detected in sun-protected skin. Sun-damaged skin, psoriatic lesional skin, and skin from lesions of poison ivy dermatitis, however, have increased levels of telomerase activity compared to sun-protected skin, although less than that detected in tumor tissue. Because telomerase activity can be found in inflammatory lesions of the skin, this indicates that telomerase activity does not always correlate with the malignant phenotype. In addition, we show that telomerase activity is localized to the epidermis of newborn foreskin, which suggests that telomerase is expressed constitutively by cells in the epidermis. Finding higher levels of telomerase activity in sun-exposed skin compared to nonexposed skin suggests that environmental factors may modulate telomerase activity. |
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| AbstractList | Telomeres are the end regions of linear chromosomes, and in normal somatic cells the lengths of telomeres shorten with successive cell divisions. Telomerase, a ribonucleoprotein enzyme, maintains the length of telomeres in immortal and germline cells. Although present in human fetal tissues, shortly after birth telomerase activity is not detectable except in germline cells, hematopoietic cells, and most human primary tumors. In the present study we show telomerase activity to be present in 73 of 77 basal cell carcinomas, 15 of 18 nonmetastatic cutaneous squamous cell carcinomas, and 6 of 7 cutaneous melanomas, contrasting with extremely low levels detected in sun-protected skin. Sun-damaged skin, psoriatic lesional skin, and skin from lesions of poison ivy dermatitis, however, have increased levels of telomerase activity compared to sun-protected skin, although less than that detected in tumor tissue. Because telomerase activity can be found in inflammatory lesions of the skin, this indicates that telomerase activity does not always correlate with the malignant phenotype. In addition, we show that telomerase activity is localized to the epidermis of newborn foreskin, which suggests that telomerase is expressed constitutively by cells in the epidermis. Finding higher levels of telomerase activity in sun-exposed skin compared to nonexposed skin suggests that environmental factors may modulate telomerase activity. |
| Author | Chaffins, Marsha Shay, Jerry W. Ogoshi, Machiko Ramirez, Ruben D. Stan Taylor, R. Piatyszek, Mieczyslaw A. |
| Author_xml | – sequence: 1 givenname: R. surname: Stan Taylor fullname: Stan Taylor, R. organization: The University of Texas Southwestern Medical Center at Dallas, Departments of Dermatology, Texas 75235, U.S.A – sequence: 2 givenname: Ruben D. surname: Ramirez fullname: Ramirez, Ruben D. organization: Cell Biology and Neuroscience, Dallas, Texas, 75235, U.S.A – sequence: 3 givenname: Machiko surname: Ogoshi fullname: Ogoshi, Machiko organization: The University of Texas Southwestern Medical Center at Dallas, Departments of Dermatology, Texas 75235, U.S.A – sequence: 4 givenname: Marsha surname: Chaffins fullname: Chaffins, Marsha organization: The University of Texas Southwestern Medical Center at Dallas, Departments of Dermatology, Texas 75235, U.S.A – sequence: 5 givenname: Mieczyslaw A. surname: Piatyszek fullname: Piatyszek, Mieczyslaw A. organization: Cell Biology and Neuroscience, Dallas, Texas, 75235, U.S.A – sequence: 6 givenname: Jerry W. surname: Shay fullname: Shay, Jerry W. organization: Cell Biology and Neuroscience, Dallas, Texas, 75235, U.S.A |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8618017$$D View this record in MEDLINE/PubMed |
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| Copyright | 1996 The Society for Investigative Dermatology, Inc |
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| Keywords | enzyme cancer dermatitis psoriasis |
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| Snippet | Telomeres are the end regions of linear chromosomes, and in normal somatic cells the lengths of telomeres shorten with successive cell divisions. Telomerase, a... |
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| SubjectTerms | Adult Aged Aged, 80 and over cancer dermatitis enzyme Female Humans Male Middle Aged psoriasis Psoriasis - enzymology Skin - enzymology Skin - pathology Skin - radiation effects Skin Neoplasms - enzymology Sunlight - adverse effects Telomerase - metabolism |
| Title | Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions |
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