Vertebrae adjacent to spinal bone lesion are inconsistent reference markers: A magnetic resonance spectroscopic viewpoint

• Published in: Journal of magnetic resonance imaging Vol. 23; no. 4; pp. 574 - 577
• Main Authors: Rumpel, Helmut, Chan, Ling Ling, Chan, Lai Peng, Png, Meng Ai, Tan, Raymond K.L., Lim, Winston E.H.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-04-2006
• Subjects: 1H MR spectroscopy; Adult; Aged; Aged, 80 and over; diffusion-weighted imaging; Female; Fractures, Spontaneous - pathology; Humans; Magnetic Resonance Spectroscopy - methods; Male; Middle Aged; Osteoporosis - pathology; relative water/lipid composition; spinal bone lesion; Spinal Diseases - pathology; Spinal Fractures - pathology; Spinal Injuries - pathology; tumor vs. trauma
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.20531

Purpose
To ascertain the suitability of vertebrae adjacent to spinal bone lesions as a signal intensity reference on MRI, and compare the MR spectroscopic appearance of vertebral body compression fractures due to malignant tumor infiltration, bone weakening (e.g., osteoporosis), and/or minor trauma.
Materials and Methods
Twenty‐five patients with spinal compression fractures underwent routine spinal MRI with an additional 1H MRS study protocol to assess the percent fat fraction of the compressed vertebrae as well as the adjacent bony environment. Peak areas for water and total lipid were calculated from short‐TE single‐voxel 1H MR spectra using the LCModel analyzing tool.
Results
There were consistent water‐only patterns in the fractured vertebra suggesting either near complete marrow replacement by malignant tissue or local edematous fluid/hemorrhage within the marrow spaces. However, the adjacent vertebrae showed a wide range of patterns from a dominant lipid signal to the inverse of a pronounced water level. These results far exceed the normal variation expected based on age and sex.
Conclusion
The results suggest that the adjacent vertebrae may not be an accurate reference, especially in diffusion‐weighted imaging (DWI), because of the large difference between the two compartments. Furthermore, in the case of gradient‐echo measurements, the in‐phase vs. opposed‐phase effects are significant. J. Magn. Reson. Imaging 2006. © 2006 Wiley‐Liss, Inc.