Melatonin's role as a co-adjuvant treatment in colonic diseases: A review

Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense syste...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 170; pp. 72 - 81
Main Authors:	Esteban-Zubero, Eduardo, López-Pingarrón, Laura, Alatorre-Jiménez, Moisés Alejandro, Ochoa-Moneo, Purificación, Buisac-Ramón, Celia, Rivas-Jiménez, Miguel, Castán-Ruiz, Silvia, Antoñanzas-Lombarte, Ángel, Tan, Dun-Xian, García, José Joaquín, Reiter, Russel J.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-02-2017 Elsevier BV
Subjects:	Adjuvant therapy Animals Antioxidants Cell Proliferation Cholecystokinin Circadian rhythms Colitis - metabolism Colitis, Ulcerative - metabolism Colonic Diseases - metabolism Constipation Crohn's Disease Crohns disease Diarrhea Digestive system Diseases Enterocolitis Enterocolitis, Necrotizing - metabolism Enzymes Food intake Gastric motility Gastrointestinal diseases Gastrointestinal Diseases - metabolism Gastrointestinal Diseases - therapy Gastrointestinal tract Gastrointestinal Tract - metabolism Gene expression Humans Immune response Immune system Inflammatory bowel disease Innate immunity Intestinal transit time Intestine Intestines - metabolism Irritable bowel syndrome Irritable Bowel Syndrome - metabolism Melatonin Melatonin - physiology Melatonin - secretion Melatonin receptors Mucosa Necrotizing enterocolitis Organs Oxidative stress Pineal gland Pineal Gland - metabolism Receptors Receptors, Melatonin - metabolism Resists Risk Factors Serotonin Serotonin - metabolism Sleep Th17 Cells - cytology Th2 Cells - cytology Transit time Ulcerative colitis Melatonin Necrotizing enterocolitis HO-1 LPO MDA HIOMT MPO UC NF-κB 6-OHMs Nrf2 RNS GRd iNOS IBS GSH EC CD CACC NQO-1 PGE2 IL SOD MT2 Crohn's disease GPx MMP IBS-D IBS-C GIT NOS TNF-α PTX-3 MEL CRF Gastrointestinal diseases CAT Irritable bowel syndrome CCK2 Keap1 5-HT HCY Ulcerative colitis
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