Melatonin's role as a co-adjuvant treatment in colonic diseases: A review

Melatonin's role as a co-adjuvant treatment in colonic diseases: A review

Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense syste...

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Published in:Life sciences (1973) Vol. 170; pp. 72 - 81
Main Authors: Esteban-Zubero, Eduardo, López-Pingarrón, Laura, Alatorre-Jiménez, Moisés Alejandro, Ochoa-Moneo, Purificación, Buisac-Ramón, Celia, Rivas-Jiménez, Miguel, Castán-Ruiz, Silvia, Antoñanzas-Lombarte, Ángel, Tan, Dun-Xian, García, José Joaquín, Reiter, Russel J.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-02-2017
Elsevier BV
Subjects:
Adjuvant therapy
Animals
Antioxidants
Cell Proliferation
Cholecystokinin
Circadian rhythms
Colitis - metabolism
Colitis, Ulcerative - metabolism
Colonic Diseases - metabolism
Constipation
Crohn's Disease
Crohns disease
Diarrhea
Digestive system
Diseases
Enterocolitis
Enterocolitis, Necrotizing - metabolism
Enzymes
Food intake
Gastric motility
Gastrointestinal diseases
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - therapy
Gastrointestinal tract
Gastrointestinal Tract - metabolism
Gene expression
Humans
Immune response
Immune system
Inflammatory bowel disease
Innate immunity
Intestinal transit time
Intestine
Intestines - metabolism
Irritable bowel syndrome
Irritable Bowel Syndrome - metabolism
Melatonin
Melatonin - physiology
Melatonin - secretion
Melatonin receptors
Mucosa
Necrotizing enterocolitis
Organs
Oxidative stress
Pineal gland
Pineal Gland - metabolism
Receptors
Receptors, Melatonin - metabolism
Resists
Risk Factors
Serotonin
Serotonin - metabolism
Sleep
Th17 Cells - cytology
Th2 Cells - cytology
Transit time
Ulcerative colitis
Melatonin
Necrotizing enterocolitis
HO-1
LPO
MDA
HIOMT
MPO
UC
NF-κB
6-OHMs
Nrf2
RNS
GRd
iNOS
IBS
GSH
EC
CD
CACC
NQO-1
PGE2
IL
SOD
MT2
Crohn's disease
GPx
MMP
IBS-D
IBS-C
GIT
NOS
TNF-α
PTX-3
MEL
CRF
Gastrointestinal diseases
CAT
Irritable bowel syndrome
CCK2
Keap1
5-HT
HCY
Ulcerative colitis
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Abstract Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression. In the gastrointestinal tract, the activities of melatonin are mediated by melatonin receptors (MT2), serotonin (5-HT), and cholecystokinin B (CCK2) receptors and via receptor-independent processes. The levels of melatonin in the gastrointestinal tract exceed by 10–100 times the blood concentrations. Also, there is an estimated 400 times more melatonin in the gut than in the pineal gland. Gut melatonin secretion is suggested to be influenced by the food intake. Low dose melatonin treatment accelerates intestinal transit time whereas high doses may decrease gut motility. Melatonin has been studied as a co-adjuvant treatment in several gastrointestinal diseases including irritable bowel syndrome (IBS), constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), Crohn's disease, ulcerative colitis, and necrotizing enterocolitis. The purpose of this review is to provide information regarding the potential benefits of melatonin as a co-adjuvant treatment in gastrointestinal diseases, especially IBS, Crohn's disease, ulcerative colitis, and necrotizing enterocolitis. [Display omitted]
AbstractList Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression. In the gastrointestinal tract, the activities of melatonin are mediated by melatonin receptors (MT2), serotonin (5-HT), and cholecystokinin B (CCK2) receptors and via receptor-independent processes. The levels of melatonin in the gastrointestinal tract exceed by 10-100 times the blood concentrations. Also, there is an estimated 400 times more melatonin in the gut than in the pineal gland. Gut melatonin secretion is suggested to be influenced by the food intake. Low dose melatonin treatment accelerates intestinal transit time whereas high doses may decrease gut motility. Melatonin has been studied as a co-adjuvant treatment in several gastrointestinal diseases including irritable bowel syndrome (IBS), constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), Crohn's disease, ulcerative colitis, and necrotizing enterocolitis. The purpose of this review is to provide information regarding the potential benefits of melatonin as a co-adjuvant treatment in gastrointestinal diseases, especially IBS, Crohn's disease, ulcerative colitis, and necrotizing enterocolitis.
Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful antioxidant that resists oxidative stress due to its capacity to directly scavenge reactive species, to modulate the antioxidant defense system by increasing the activities of antioxidant enzymes, and to stimulate the innate immune response through its direct and indirect actions. In addition, the dysregulation of the circadian system is observed to be related with alterations in colonic motility and cell disruptions due to the modifications of clock genes expression. In the gastrointestinal tract, the activities of melatonin are mediated by melatonin receptors (MT2), serotonin (5-HT), and cholecystokinin B (CCK2) receptors and via receptor-independent processes. The levels of melatonin in the gastrointestinal tract exceed by 10–100 times the blood concentrations. Also, there is an estimated 400 times more melatonin in the gut than in the pineal gland. Gut melatonin secretion is suggested to be influenced by the food intake. Low dose melatonin treatment accelerates intestinal transit time whereas high doses may decrease gut motility. Melatonin has been studied as a co-adjuvant treatment in several gastrointestinal diseases including irritable bowel syndrome (IBS), constipation-predominant IBS (IBS-C), diarrhea-predominant IBS (IBS-D), Crohn's disease, ulcerative colitis, and necrotizing enterocolitis. The purpose of this review is to provide information regarding the potential benefits of melatonin as a co-adjuvant treatment in gastrointestinal diseases, especially IBS, Crohn's disease, ulcerative colitis, and necrotizing enterocolitis. [Display omitted]
Author López-Pingarrón, Laura
Esteban-Zubero, Eduardo
Ochoa-Moneo, Purificación
Rivas-Jiménez, Miguel
Castán-Ruiz, Silvia
Tan, Dun-Xian
García, José Joaquín
Reiter, Russel J.
Buisac-Ramón, Celia
Alatorre-Jiménez, Moisés Alejandro
Antoñanzas-Lombarte, Ángel
Author_xml – sequence: 1
  givenname: Eduardo
  orcidid: 0000-0003-3957-3749
  surname: Esteban-Zubero
  fullname: Esteban-Zubero, Eduardo
  email: eezubero@gmail.com
  organization: Department of Pharmacology and Physiology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 2
  givenname: Laura
  surname: López-Pingarrón
  fullname: López-Pingarrón, Laura
  organization: Department of Medicine, Psychiatry and Dermatology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 3
  givenname: Moisés Alejandro
  surname: Alatorre-Jiménez
  fullname: Alatorre-Jiménez, Moisés Alejandro
  organization: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
– sequence: 4
  givenname: Purificación
  surname: Ochoa-Moneo
  fullname: Ochoa-Moneo, Purificación
  organization: Department of Medicine, Psychiatry and Dermatology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 5
  givenname: Celia
  surname: Buisac-Ramón
  fullname: Buisac-Ramón, Celia
  organization: Primary Care Unit, Sector Zaragoza III, Avenida San Juan Bosco 5, 50009 Zaragoza, Spain
– sequence: 6
  givenname: Miguel
  surname: Rivas-Jiménez
  fullname: Rivas-Jiménez, Miguel
  organization: Department of Medicine, Psychiatry and Dermatology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 7
  givenname: Silvia
  surname: Castán-Ruiz
  fullname: Castán-Ruiz, Silvia
  organization: Primary Care Unit, Sector Zaragoza III, Avenida San Juan Bosco 5, 50009 Zaragoza, Spain
– sequence: 8
  givenname: Ángel
  surname: Antoñanzas-Lombarte
  fullname: Antoñanzas-Lombarte, Ángel
  organization: Department of Medicine, Psychiatry and Dermatology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 9
  givenname: Dun-Xian
  surname: Tan
  fullname: Tan, Dun-Xian
  organization: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
– sequence: 10
  givenname: José Joaquín
  surname: García
  fullname: García, José Joaquín
  organization: Department of Pharmacology and Physiology, University of Zaragoza. Calle Domingo Miral s/n, 50009 Zaragoza, Spain
– sequence: 11
  givenname: Russel J.
  surname: Reiter
  fullname: Reiter, Russel J.
  email: reiter@uthscsa.edu
  organization: Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27919824$$D View this record in MEDLINE/PubMed
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EISSN 1879-0631
EndPage 81
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ID FETCH-LOGICAL-c490t-ec477180083d5c8398b4a4e655d73d5a5f7ce863467aede345a6e0a49ede7f493
ISSN 0024-3205
IngestDate Fri Oct 25 09:35:34 EDT 2024
Thu Oct 17 03:53:29 EDT 2024
Thu Sep 26 21:41:09 EDT 2024
Sat Sep 28 07:59:33 EDT 2024
Fri Feb 23 02:25:41 EST 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Keywords Melatonin
Necrotizing enterocolitis
HO-1
LPO
MDA
HIOMT
MPO
UC
NF-κB
6-OHMs
Nrf2
RNS
GRd
iNOS
IBS
GSH
EC
CD
CACC
NQO-1
PGE2
IL
SOD
MT2
Crohn's disease
GPx
MMP
IBS-D
IBS-C
GIT
NOS
TNF-α
PTX-3
MEL
CRF
Gastrointestinal diseases
CAT
Irritable bowel syndrome
CCK2
Keap1
5-HT
HCY
Ulcerative colitis
Language English
License Copyright © 2016 Elsevier Inc. All rights reserved.
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ORCID 0000-0003-3957-3749
OpenAccessLink https://zaguan.unizar.es/record/79364/files/texto_completo.pdf
PMID 27919824
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PublicationCentury 2000
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PublicationTitle Life sciences (1973)
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Snippet Melatonin is produced in the pineal gland as well as many other organs, including the enterochromaffin cells of the digestive mucosa. Melatonin is a powerful...
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SubjectTerms Adjuvant therapy
Animals
Antioxidants
Cell Proliferation
Cholecystokinin
Circadian rhythms
Colitis - metabolism
Colitis, Ulcerative - metabolism
Colonic Diseases - metabolism
Constipation
Crohn's Disease
Crohns disease
Diarrhea
Digestive system
Diseases
Enterocolitis
Enterocolitis, Necrotizing - metabolism
Enzymes
Food intake
Gastric motility
Gastrointestinal diseases
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - therapy
Gastrointestinal tract
Gastrointestinal Tract - metabolism
Gene expression
Humans
Immune response
Immune system
Inflammatory bowel disease
Innate immunity
Intestinal transit time
Intestine
Intestines - metabolism
Irritable bowel syndrome
Irritable Bowel Syndrome - metabolism
Melatonin
Melatonin - physiology
Melatonin - secretion
Melatonin receptors
Mucosa
Necrotizing enterocolitis
Organs
Oxidative stress
Pineal gland
Pineal Gland - metabolism
Receptors
Receptors, Melatonin - metabolism
Resists
Risk Factors
Serotonin
Serotonin - metabolism
Sleep
Th17 Cells - cytology
Th2 Cells - cytology
Transit time
Ulcerative colitis
Title Melatonin's role as a co-adjuvant treatment in colonic diseases: A review
URI https://dx.doi.org/10.1016/j.lfs.2016.11.031
https://www.ncbi.nlm.nih.gov/pubmed/27919824
https://www.proquest.com/docview/1940517917
https://search.proquest.com/docview/1846370984
Volume 170
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