Genomic strategies for personalized cancer therapy

• Published in: Human molecular genetics Vol. 16; no. R2; pp. R226 - R232
• Main Authors: Garman, Katherine S., Nevins, Joseph R., Potti, Anil
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 15-10-2007
• Subjects: Antineoplastic Agents - therapeutic use; Biological and medical sciences; Biological Products - therapeutic use; Breast Neoplasms - genetics; Breast Neoplasms - therapy; Combined Modality Therapy; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Profiling; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Genomics; Humans; Molecular and cellular biology; Neoplasms - genetics; Neoplasms - therapy; Prognosis; Genetics; Malignant tumor; Genomics; Cancer
• ISSN: 0964-6906; 1460-2083
• DOI: 10.1093/hmg/ddm184

Numerous recent studies have demonstrated the use of genomic data, particularly gene expression signatures, as clinical prognostic factors in cancer and other complex diseases. These studies highlight the opportunity for strategies to achieve truly personalized cancer treatment. In particular, the ability to develop gene expression signatures will likely allow us to guide the use of currently available cancer drugs, develop new targeted therapeutics, and provide an opportunity to better match the most effective drug or drugs with the molecular characteristics of the individual patient.