Aging, Neurodegenerative Disorders, and Cerebellum

Aging, Neurodegenerative Disorders, and Cerebellum

An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's...

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Published in:International journal of molecular sciences Vol. 25; no. 2; p. 1018
Main Authors: Iskusnykh, Igor Y, Zakharova, Anastasia A, Kryl'skii, Evgenii D, Popova, Tatyana N
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01-01-2024
Subjects:
Advertising executives
Age
Aging
Alzheimer Disease
Alzheimer's disease
Amyotrophic lateral sclerosis
Ataxia
Brain
Cerebellum
Cognition & reasoning
Cognitive ability
Cytochrome
Dehydrogenases
Development and progression
Humans
Huntington Disease
Huntingtons disease
Metabolism
Mitochondria
Multiple sclerosis
Nervous system diseases
Neurodegeneration
Neurodegenerative Diseases
neuron
Proteins
Purkinje cells
Alzheimer’s disease
Purkinje cells
granule cells
inflammation
neurodegeneration
neuron
dementia
aging
brain
cerebellum
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Abstract An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's disease (AD), vascular dementia (VD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.
AbstractList An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer’s disease (AD), vascular dementia (VD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich’s ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.
An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's disease (AD), vascular dementia (VD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished cerebellar function results in the motor and cognitive impairment observed in patients with neurodegenerative disorders such as Alzheimer's disease (AD), vascular dementia (VD), Parkinson's disease (PD), Huntington's disease (HD), spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS), Friedreich's ataxia (FRDA), and multiple sclerosis (MS), and even during the normal aging process. In most neurodegenerative disorders, impairment mainly occurs as a result of morphological changes over time, although during the early stages of some disorders such as AD, the cerebellum also serves a compensatory function. Biological aging is accompanied by changes in cerebellar circuits, which are predominantly involved in motor control. Despite decades of research, the functional contributions of the cerebellum and the underlying molecular mechanisms in aging and neurodegenerative disorders remain largely unknown. Therefore, this review will highlight the molecular and cellular events in the cerebellum that are disrupted during the process of aging and the development of neurodegenerative disorders. We believe that deeper insights into the pathophysiological mechanisms of the cerebellum during aging and the development of neurodegenerative disorders will be essential for the design of new effective strategies for neuroprotection and the alleviation of some neurodegenerative disorders.
Audience Academic
Author Kryl'skii, Evgenii D
Iskusnykh, Igor Y
Zakharova, Anastasia A
Popova, Tatyana N
Author_xml – sequence: 1
  givenname: Igor Y
  orcidid: 0000-0002-1207-6075
  surname: Iskusnykh
  fullname: Iskusnykh, Igor Y
  organization: Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
– sequence: 2
  givenname: Anastasia A
  surname: Zakharova
  fullname: Zakharova, Anastasia A
  organization: Department of Medical Biochemistry, Faculty of Biomedicine, Pirogov Russian National Research Medical University, Ostrovitianov St. 1, Moscow 117997, Russia
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  givenname: Evgenii D
  orcidid: 0000-0002-8855-5515
  surname: Kryl'skii
  fullname: Kryl'skii, Evgenii D
  organization: Department of Medical Biochemistry, Molecular and Cell Biology, Voronezh State University, Universitetskaya Sq. 1, Voronezh 394018, Russia
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  givenname: Tatyana N
  orcidid: 0000-0002-9660-3054
  surname: Popova
  fullname: Popova, Tatyana N
  organization: Department of Medical Biochemistry, Molecular and Cell Biology, Voronezh State University, Universitetskaya Sq. 1, Voronezh 394018, Russia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38256091$$D View this record in MEDLINE/PubMed
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Keywords Alzheimer’s disease
Purkinje cells
granule cells
inflammation
neurodegeneration
neuron
dementia
aging
brain
cerebellum
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Snippet An important part of the central nervous system (CNS), the cerebellum is involved in motor control, learning, reflex adaptation, and cognition. Diminished...
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SubjectTerms Advertising executives
Age
Aging
Alzheimer Disease
Alzheimer's disease
Amyotrophic lateral sclerosis
Ataxia
Brain
Cerebellum
Cognition & reasoning
Cognitive ability
Cytochrome
Dehydrogenases
Development and progression
Humans
Huntington Disease
Huntingtons disease
Metabolism
Mitochondria
Multiple sclerosis
Nervous system diseases
Neurodegeneration
Neurodegenerative Diseases
neuron
Proteins
Purkinje cells
Title Aging, Neurodegenerative Disorders, and Cerebellum
URI https://www.ncbi.nlm.nih.gov/pubmed/38256091
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Volume 25
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