New Tools for Epilepsy Therapy

• Published in: Frontiers in cellular neuroscience Vol. 12; p. 147
• Main Authors: Falcicchia, Chiara, Simonato, Michele, Verlengia, Gianluca
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 29-05-2018; Frontiers Media S.A
• Subjects: Antiepileptic agents; Brain; cell therapy; Convulsions & seizures; delivery devices; Drug resistance; Epilepsy; Expression vectors; Gene therapy; Growth factors; herpes-based vector; Neurological disorders; Neuroscience; Neurosciences; Stem cells; Surgery; Transplants & implants; Vectors (Biology); Italy; epilepsy; gene therapy; delivery devices; cell therapy; herpes-based vector
• ISSN: 1662-5102; 1662-5102
• DOI: 10.3389/fncel.2018.00147

One third of the epilepsies are refractory to conventional antiepileptic drugs (AEDs) and, therefore, identification of new therapies is highly needed. Here, we briefly describe two approaches, direct cell grafting and gene therapy, that may represent alternatives to conventional drugs for the treatment of focal epilepsies. In addition, we discuss more in detail some new tools, cell based-biodelivery systems (encapsulated cell biodelivery (ECB) devices) and new generation gene therapy vectors, which may help in the progress toward clinical translation. The field is advancing rapidly, and there is optimism that cell and/or gene therapy strategies will soon be ready for testing in drug-resistant epileptic patients.