High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor

Hepatitis C virus (HCV) infections pose a major public health burden due to high chronicity rates and associated morbidity and mortality. A vaccine protecting against chronic infection is not available but would be important for global control of HCV infections. In this study, cell culture-based HCV...

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Bibliographic Details
Published in:	Vaccines (Basel) Vol. 10; no. 2; p. 249
Main Authors:	Offersgaard, Anna, Duarte Hernandez, Carlos Rene, Pihl, Anne Finne, Venkatesan, Nandini Prabhakar, Krarup, Henrik, Lin, Xiangliang, Reichl, Udo, Bukh, Jens, Genzel, Yvonne, Gottwein, Judith Margarete
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 07-02-2022 MDPI
Subjects:	Antibodies Bioreactors CelCradle Cell culture Cell density Chronic infection Density Efficiency Experiments Good Manufacturing Practice Hepatitis Hepatitis C Hepatoma high cell density cell culture Huh7.5 cells Immunization Immunology inactivated virus vaccine Infections Infectivity Morbidity Motion systems Neutralization packed-bed bioreactor Proteins Public health Serum-free medium Severe acute respiratory syndrome coronavirus 2 Vaccines Vessels Viruses whole virus vaccine Singapore Huh7.5 cells high cell density cell culture packed-bed bioreactor inactivated virus vaccine CelCradle high-titer HCV production HCV vaccine development whole virus vaccine
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