Discovery of Levesquamide B through Global Natural Product Social Molecular Networking

Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, is...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 22; p. 7794
Main Authors:	LeClair, Mary M, Maw, Zacharie A, Grunwald, Alyssa L, Kelly, Joshua R, Haltli, Bradley A, Kerr, Russell G, Cartmell, Christopher
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 12-11-2022 MDPI
Subjects:	Amino acids Antifungal agents Biological Products - chemistry Biosynthesis Cancer Carbon Glucose GNPS Hypotheses Isothiazolinone levesquamide marine natural product Microorganisms Natural products Networking Social networks Social organization Streptomyces Canada Prince Edward Island Streptomyces levesquamide GNPS marine natural product
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Summary:	Levesquamide A is an isothiazolinone-containing anti-tubercular natural product isolated from sp. RKND-216. Through the use of Global Natural Product Social Molecular Networking (GNPS), additional members of the levesquamide family were identified (B-G). Levesquamide B is a glycosylated analogue, isolated and structurally elucidated via spectroscopical techniques along with the putative structures of levesquamide C and D. For masses relating to the additional three levesquamides (E-G), their complete structures remain ambiguous.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27227794