Development and design of double-layer co-injection moulded soy protein based drug delivery devices

• Published in: Polymer (Guilford) Vol. 44; no. 19; pp. 5983 - 5992
• Main Authors: Vaz, Cláudia M, van Doeveren, P.F.N.M, Reis, R.L, Cunha, A.M
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-09-2003; Elsevier
• Subjects: Applied sciences; behavior; biodegradable polymers; Biological and medical sciences; biomedical applications; Composites; diffusional matrices; Double-layer delivery device; Exact sciences and technology; extrusion; Forms of application and semi-finished materials; General pharmacology; in-vitro; kinetics; mechanical-properties; Medical sciences; Mono-sandwich injection molding; order sustained-release; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Polymer industry, paints, wood; Soy protein derived material; Technology of polymers; thermoplastics; Mono-sandwich injection molding; Soy protein derived material; Double-layer delivery device; Molten state; Control release polymer; Mechanical properties; Drug carrier; Hydroxyapatite; Dispersion reinforced material; Protein isolate; Antiasthma agent; Experimental study; Composite material; Soy protein; Manufacturing process; Morphology; Injection molding; Kinetics; Release; Theophylline; Bilayers; Rheological properties
• ISSN: 0032-3861; 1873-2291
• DOI: 10.1016/S0032-3861(03)00549-4

Novel double-layer delivery devices based on soy protein derived materials were designed and produced using an innovative two material co-injection moulding technique. It was demonstrated that the viscosity ratio between core and skin layer materials played an important role in the formation of the interfacial shape, namely the skin thickness and uniformity of the bi-materials. The adequate selection of the materials used and the optimisation of the respective processing conditions enabled an accurate control of the relative thickness of the layers of the device. The preliminary results confirmed the potential of these systems to achieve a controlled drug delivery.