Bilateral Wilms tumors treated according to the Japan Wilms Tumor Study Group protocol
Background The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the...
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| Published in: | Pediatric blood & cancer Vol. 61; no. 7; pp. 1184 - 1189 |
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01-07-2014
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| Abstract | Background
The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS).
Procedure
This analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed.
Results
Among the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron‐sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5‐year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure.
Conclusions
The long‐term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. Pediatr Blood Cancer 2014;61:1184–1189. © 2014 Wiley Periodicals, Inc. |
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| AbstractList | BACKGROUNDThe introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS).PROCEDUREThis analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed.RESULTSAmong the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron-sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5-year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure.CONCLUSIONSThe long-term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS). This analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed. Among the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron-sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5-year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure. The long-term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. Background The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS). Procedure This analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed. Results Among the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron-sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5-year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure. Conclusions The long-term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. Pediatr Blood Cancer 2014; 61:1184-1189. Background The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS). Procedure This analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed. Results Among the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron-sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5-year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure. Conclusions The long-term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. Pediatr Blood Cancer 2014;61:1184-1189. © 2014 Wiley Periodicals, Inc. Background The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms of the renal preservation. To establish a new treatment strategy for BWT, we reviewed the results of the cases registered in the Japan Wilms Tumor Study Group (JWiTS). Procedure This analysis concerned patients with synchronous BWT registered in the JWiTS between 1996 and 2011. In these patients, the management of BWT included initial tumor resection or biopsy followed by chemotherapy. The details of the treatments and outcomes were analyzed. Results Among the 355 cases registered in the JWiTS database, 31 (8.7%) had BWT. They were 16 males and 15 females with a mean age of 15.5 months. Preoperative chemotherapy was performed in 24 cases. Bilateral nephron‐sparing surgery (NSS) was achieved in 10 of 28 cases (36%). All of the cases were of favorable nephroblastoma without anaplasia, and a WT1 mutation was detected in 21 of the 27 cases (78%) examined. The 5‐year overall survival was 92.6%; however, 10 children (40%) developed impaired renal function and three of them developed renal failure. Conclusions The long‐term survival rates for patients with synchronous BWT have improved. However, more than half of patients receive nephrectomy. The protocol should be changed to improve the rate of preservation of the renal parenchyma. Preoperative chemotherapy should be performed to shrink the tumors in every case, and subsequent NSS should be carried out after a central imaging evaluation. Pediatr Blood Cancer 2014;61:1184–1189. © 2014 Wiley Periodicals, Inc. |
| Author | Hinotsu, Shiro Koshinaga, Tsugumichi Okita, Hajime Kaneko, Yasuhiko Fukuzawa, Masahiro Oue, Takaharu |
| Author_xml | – sequence: 1 givenname: Takaharu surname: Oue fullname: Oue, Takaharu email: Correspondence to: Takaharu Oue, Department of Pediatric Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan., ooue@pedsurg.med.osaka-u.ac.jp organization: Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Osaka, Japan – sequence: 2 givenname: Tsugumichi surname: Koshinaga fullname: Koshinaga, Tsugumichi organization: Department of Pediatric Surgery, Nihon University School of Medicine, Tokyo, Japan – sequence: 3 givenname: Hajime surname: Okita fullname: Okita, Hajime organization: National Center for Child Health and Development, Tokyo, Japan – sequence: 4 givenname: Yasuhiko surname: Kaneko fullname: Kaneko, Yasuhiko organization: Research Institute for Clinical Oncology, Saitama Cancer Center, Saitama, Japan – sequence: 5 givenname: Shiro surname: Hinotsu fullname: Hinotsu, Shiro organization: Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan – sequence: 6 givenname: Masahiro surname: Fukuzawa fullname: Fukuzawa, Masahiro organization: Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan |
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| Cites_doi | 10.1002/ijc.1475 10.1016/j.juro.2011.03.110 10.1200/JCO.1989.7.3.310 10.1097/SLA.0b013e31821266a0 10.1136/jmg.39.12.e83 10.1016/S0022-5347(17)37840-0 10.1002/gcc.20572 10.1016/S0022-3468(96)90077-9 10.1007/s00383-009-2449-0 10.1002/cncr.23406 10.1016/j.jpedsurg.2005.12.004 10.1016/j.jpedsurg.2004.07.009 10.1002/pbc.24059 10.1097/01.ju.0000176800.00994.3a 10.1002/1097-0142(19930815)72:4<1422::AID-CNCR2820720443>3.0.CO;2-E 10.1200/JCO.1998.16.11.3634 10.1097/01.mph.0000212995.56812.bb 10.1016/S0022-5347(01)62588-6 10.1016/S0022-5347(17)43474-4 10.1002/mpo.2950210303 10.1007/s00467-012-2140-x 10.1002/cncr.21979 10.1111/j.1349-7006.2012.02269.x |
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| References | Horwitz JR, Ritchey MR, Moksness J, et al. Renal salvage procedure in patients with synchronous bilateral Wilms' tumor: A report from the National Wilms' Tumor Study Group. J Pediatr Surg 1996; 31:1020-1025. Breslow NE, Takashima JR, Ritchey ML, et al. Renal failure in the Denys-Drash and Wilms' tumoraniridia syndromes. Cancer Res 2000; 60:4030-4032. Hamilton TE, Ritchey ML, Haase GM, et al. The management of synchronous bilateral Wilms tumor: A report of the National Wilms Tumor Study Group. Ann Surg 2011; 253:1004-1010. Grigoriev Y, Lange J, Peterson SM, et al. Treatments and outcomes for end stage renal disease following Wilms tumor. Pediatr Nephrol 2012; 27:1325-1333. Shibata R, Hashiguchi A, Sakamoto J, et al. Correlation between a specific Wilms tumour suppressor gene (WT1) mutation and the histological findings in Wilms tumour (WT). J Med Genet 2002; 39:e83. Hamilton TE, Ritchey ML, Haase GM, et al. The management of synchronous bilateral Wilms tumor: A report from the National Wilms Tumor Study Group. Ann Surg 2011; 253:1004-1010. Haruta M, Arai Y, Sugawara W, et al. Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities. Genes Chromosomes Cancer 2008; 47. Nakadate H, Yokomori K, Watanabe N, et al. Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan. Int J Cancer 2001; 94:396-400. Breslow NE, Collins AJ, Ritchey ML, et al. End stage renal disease in patients with Wilms' tumor: Results from the National Wilms' Tumor Study Group and the United States Renal Data System. J Urol 2005; 174:1972-1975. Montgomery BT, Kelalis PP, Blute ML, et al. Extended follow up of bilateral Wilms' tumor: Results of the National Wilms' Tumor Study. J Urol 1991; 146:514-518. Madre C, Orbach D, Baudouin V, et al. Hypertension in childhood cancer: A frequent complication of certain tumor sites. J Pediatr Hematol Oncol 2006; 28:659-664. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481. Sudour H, Audry G, Schleimacher G, et al. Bilateral Wilms tumors (WT) treated with the SIOP 93 protocol in France: Epidemiological survey and patient outcome. Pediatr Blood Cancer 2012; 59:57-61. Kumar R, Fitzgerald R, Breatnach F. Conservative surgical management of bilateral Wilms' tumor: Results of the United Kingdom Children's Cancer Study Group. J Urol 1998; 160:1450-1453. Haruta M, Arai Y, Watanabe N, et al. Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children. Cancer Sci 2012; 103:1129-1135. Oue T, Fukuzawa M, Okita H, et al. Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study-1 (JWiTS-1) protocol: A report from the JWiTS group. Pediatr Surg Int 2009; 25:923-929. Beckwith JB. Precursor lesions of Wilms tumor: Clinical and pathological implications. Med Pediatr Oncol 1993; 21:158-168. Davidoff AM, Giel DW, Jones DP, et al. The feasibility and outcome of nephron-sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999-2006. Cancer 2008; 112:2060-2070. Kubiak R, Gundeti M, Duffy PG, et al. Renal function and outcome following salvage surgery for bilateral Wilms' tumor. J Pediatr Surg 2004; 3:1667-1672. Blute ML, Kelalis PP, Offord KP, et al. Bilateral Wilms' tumor. J Urol 1987; 138:968-973. Shearer P, Parham DM, Fontanesi J, et al. Bilateral Wilms' tumor: Review of outcome, associated abnormalities, and late effects in 36 pediatric patients treated at a single institution. Cancer 1993; 72:1422-1426. Shamberger RC, Haase GM, Argani P, et al. Bilateral Wilms' tumors with progressive or nonresponsive disease. J Pediatr Surg 2006; 41:652-657. Coppes MJ, de Kraker J, Van Dijken PJ, et al. Bilateral Wilms' tumor: Long term survival and some epidemiological features. J Clin Oncol 1989; 7:310-315. Lange J, Peterson SM, Takashima JR, et al. Risk factors for end stage renal disease in non-WT1-syndromic Wilms tumor. J Urol 2011; 186:378-386. Peterson SM, Takashima JR, Grivoriev Y, et al. Risk factors for end stage renal disease in non-WT1-syndromic Wilms tumor. J Urol 2011; 186:378-386. Diller L, Ghahremani M, Morgan J, et al. Frequency of constitutional mutations in the WT1 gene in patients with Wilms tumors. J Clin Oncol 1998; 16:3634-3640. 1998; 16 2002; 39 1998; 160 2009; 25 2001; 94 2006; 41 1991; 146 2005; 174 1987; 138 1993; 72 1989; 7 2006; 28 1993; 21 1958; 53 2008; 47 2004; 3 2000; 60 2012; 27 2012; 59 2008; 112 2012; 103 1996; 31 2011; 253 2011; 186 e_1_2_5_27_1 e_1_2_5_25_1 e_1_2_5_26_1 e_1_2_5_24_1 e_1_2_5_21_1 e_1_2_5_22_1 e_1_2_5_20_1 e_1_2_5_15_1 e_1_2_5_14_1 e_1_2_5_17_1 e_1_2_5_9_1 e_1_2_5_16_1 e_1_2_5_8_1 e_1_2_5_11_1 e_1_2_5_7_1 e_1_2_5_10_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 e_1_2_5_19_1 e_1_2_5_18_1 Breslow NE (e_1_2_5_23_1) 2000; 60 |
| References_xml | – volume: 3 start-page: 1667 year: 2004 end-page: 1672 article-title: Renal function and outcome following salvage surgery for bilateral Wilms' tumor publication-title: J Pediatr Surg – volume: 160 start-page: 1450 year: 1998 end-page: 1453 article-title: Conservative surgical management of bilateral Wilms' tumor: Results of the United Kingdom Children's Cancer Study Group publication-title: J Urol – volume: 103 start-page: 1129 year: 2012 end-page: 1135 article-title: Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children publication-title: Cancer Sci – volume: 186 start-page: 378 year: 2011 end-page: 386 article-title: Risk factors for end stage renal disease in non‐WT1‐syndromic Wilms tumor publication-title: J Urol – volume: 41 start-page: 652 year: 2006 end-page: 657 article-title: Bilateral Wilms' tumors with progressive or nonresponsive disease publication-title: J Pediatr Surg – volume: 186 start-page: 378 year: 2011 end-page: 386 article-title: Risk factors for end stage renal disease in non‐ ‐syndromic Wilms tumor publication-title: J Urol – volume: 28 start-page: 659 year: 2006 end-page: 664 article-title: Hypertension in childhood cancer: A frequent complication of certain tumor sites publication-title: J Pediatr Hematol Oncol – volume: 7 start-page: 310 year: 1989 end-page: 315 article-title: Bilateral Wilms' tumor: Long term survival and some epidemiological features publication-title: J Clin Oncol – volume: 31 start-page: 1020 year: 1996 end-page: 1025 article-title: Renal salvage procedure in patients with synchronous bilateral Wilms' tumor: A report from the National Wilms' Tumor Study Group publication-title: J Pediatr Surg – volume: 72 start-page: 1422 year: 1993 end-page: 1426 article-title: Bilateral Wilms' tumor: Review of outcome, associated abnormalities, and late effects in 36 pediatric patients treated at a single institution publication-title: Cancer – volume: 27 start-page: 1325 year: 2012 end-page: 1333 article-title: Treatments and outcomes for end stage renal disease following Wilms tumor publication-title: Pediatr Nephrol – volume: 253 start-page: 1004 year: 2011 end-page: 1010 article-title: The management of synchronous bilateral Wilms tumor: A report of the National Wilms Tumor Study Group publication-title: Ann Surg – volume: 39 start-page: e83 year: 2002 article-title: Correlation between a specific Wilms tumour suppressor gene (WT1) mutation and the histological findings in Wilms tumour (WT) publication-title: J Med Genet – volume: 174 start-page: 1972 year: 2005 end-page: 1975 article-title: End stage renal disease in patients with Wilms' tumor: Results from the National Wilms' Tumor Study Group and the United States Renal Data System publication-title: J Urol – volume: 53 start-page: 457 year: 1958 end-page: 481 article-title: Nonparametric estimation from incomplete observations publication-title: J Am Stat Assoc – volume: 16 start-page: 3634 year: 1998 end-page: 3640 article-title: Frequency of constitutional mutations in the WT1 gene in patients with Wilms tumors publication-title: J Clin Oncol – volume: 25 start-page: 923 year: 2009 end-page: 929 article-title: Outcome of pediatric renal tumor treated using the Japan Wilms Tumor Study‐1 (JWiTS‐1) protocol: A report from the JWiTS group publication-title: Pediatr Surg Int – volume: 21 start-page: 158 year: 1993 end-page: 168 article-title: Precursor lesions of Wilms tumor: Clinical and pathological implications publication-title: Med Pediatr Oncol – volume: 47 year: 2008 article-title: Duplication of paternal IGF2 or loss of maternal IGF2 imprinting occurs in half of Wilms tumors with various structural WT1 abnormalities publication-title: Genes Chromosomes Cancer – volume: 138 start-page: 968 year: 1987 end-page: 973 article-title: Bilateral Wilms' tumor publication-title: J Urol – volume: 146 start-page: 514 year: 1991 end-page: 518 article-title: Extended follow up of bilateral Wilms' tumor: Results of the National Wilms' Tumor Study publication-title: J Urol – volume: 253 start-page: 1004 year: 2011 end-page: 1010 article-title: The management of synchronous bilateral Wilms tumor: A report from the National Wilms Tumor Study Group publication-title: Ann Surg – volume: 94 start-page: 396 year: 2001 end-page: 400 article-title: Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan publication-title: Int J Cancer – volume: 60 start-page: 4030 year: 2000 end-page: 4032 article-title: Renal failure in the Denys‐Drash and Wilms' tumoraniridia syndromes publication-title: Cancer Res – volume: 112 start-page: 2060 year: 2008 end-page: 2070 article-title: The feasibility and outcome of nephron‐sparing surgery for children with bilateral Wilms tumor. The St Jude Children's Research Hospital experience: 1999–2006 publication-title: Cancer – volume: 59 start-page: 57 year: 2012 end-page: 61 article-title: Bilateral Wilms tumors (WT) treated with the SIOP 93 protocol in France: Epidemiological survey and patient outcome publication-title: Pediatr Blood Cancer – ident: e_1_2_5_20_1 doi: 10.1002/ijc.1475 – ident: e_1_2_5_19_1 doi: 10.1016/j.juro.2011.03.110 – ident: e_1_2_5_3_1 doi: 10.1200/JCO.1989.7.3.310 – ident: e_1_2_5_6_1 doi: 10.1097/SLA.0b013e31821266a0 – ident: e_1_2_5_25_1 doi: 10.1016/j.juro.2011.03.110 – ident: e_1_2_5_8_1 doi: 10.1136/jmg.39.12.e83 – ident: e_1_2_5_12_1 doi: 10.1016/S0022-5347(17)37840-0 – ident: e_1_2_5_21_1 doi: 10.1002/gcc.20572 – ident: e_1_2_5_10_1 doi: 10.1016/S0022-3468(96)90077-9 – ident: e_1_2_5_7_1 doi: 10.1007/s00383-009-2449-0 – ident: e_1_2_5_17_1 doi: 10.1002/cncr.23406 – ident: e_1_2_5_4_1 doi: 10.1016/j.jpedsurg.2005.12.004 – ident: e_1_2_5_2_1 doi: 10.1016/j.jpedsurg.2004.07.009 – ident: e_1_2_5_16_1 doi: 10.1002/pbc.24059 – ident: e_1_2_5_24_1 doi: 10.1097/01.ju.0000176800.00994.3a – ident: e_1_2_5_13_1 doi: 10.1002/1097-0142(19930815)72:4<1422::AID-CNCR2820720443>3.0.CO;2-E – ident: e_1_2_5_26_1 doi: 10.1200/JCO.1998.16.11.3634 – ident: e_1_2_5_18_1 doi: 10.1097/SLA.0b013e31821266a0 – ident: e_1_2_5_14_1 doi: 10.1097/01.mph.0000212995.56812.bb – ident: e_1_2_5_5_1 doi: 10.1016/S0022-5347(01)62588-6 – volume: 60 start-page: 4030 year: 2000 ident: e_1_2_5_23_1 article-title: Renal failure in the Denys‐Drash and Wilms' tumoraniridia syndromes publication-title: Cancer Res contributor: fullname: Breslow NE – ident: e_1_2_5_11_1 doi: 10.1016/S0022-5347(17)43474-4 – ident: e_1_2_5_15_1 doi: 10.1002/mpo.2950210303 – ident: e_1_2_5_27_1 doi: 10.1007/s00467-012-2140-x – ident: e_1_2_5_9_1 doi: 10.1002/cncr.21979 – ident: e_1_2_5_22_1 doi: 10.1111/j.1349-7006.2012.02269.x |
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The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not... The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not satisfactory in terms... Background The introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not... BACKGROUNDThe introduction of multimodal therapy has improved the survival rate of bilateral Wilms tumors (BWT); however, the results are still not... |
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| SubjectTerms | Antineoplastic Combined Chemotherapy Protocols - administration & dosage Asian Continental Ancestry Group bilateral chemotherapy Child Child, Preschool Databases, Factual Disease-Free Survival Female Hematology Humans Infant Japan - epidemiology JWiTS Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - therapy Male nephron-sparing surgery Oncology Pediatrics Retrospective Studies Survival Rate Wilms tumor Wilms Tumor - mortality Wilms Tumor - pathology Wilms Tumor - therapy |
| Title | Bilateral Wilms tumors treated according to the Japan Wilms Tumor Study Group protocol |
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