Perilipin-2 Deletion Impairs Hepatic Lipid Accumulation by Interfering with Sterol Regulatory Element-binding Protein (SREBP) Activation and Altering the Hepatic Lipidome

Perilipin-2 (PLIN2) is a constitutively associated cytoplasmic lipid droplet coat protein that has been implicated in fatty liver formation in non-alcoholic fatty liver disease. Mice with or without whole-body deletion of perilipin-2 (Plin2-null) were fed either Western or control diets for 30 weeks...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 291; no. 46; pp. 24231 - 24246
Main Authors:	Libby, Andrew E., Bales, Elise, Orlicky, David J., McManaman, James L.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11-11-2016 American Society for Biochemistry and Molecular Biology
Subjects:	Animals Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism endoplasmic reticulum stress (ER stress) Fatty Acids, Omega-3 - genetics Fatty Acids, Omega-3 - metabolism Fatty Acids, Omega-6 - genetics Fatty Acids, Omega-6 - metabolism gene knockout Intracellular Membranes - metabolism lipid droplet Lipid Metabolism lipogenesis Liver - metabolism Liver - pathology mass spectrometry (MS) membrane lipid metabolic disease Mice Mice, Knockout Molecular Bases of Disease Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology perilipin-2 Perilipin-2 - genetics Perilipin-2 - metabolism Sterol Regulatory Element Binding Protein 1 - genetics Sterol Regulatory Element Binding Protein 1 - metabolism lipid droplet gene knockout membrane lipid lipid metabolism perilipin-2 endoplasmic reticulum stress (ER stress) liver metabolism lipogenesis metabolic disease mass spectrometry (MS)
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