Ingestion of ferrous sulfate increases ferremia in patients with short bowel syndrome

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 25; no. 11; pp. 1115 - 1119
• Main Authors: Gabriel, Fabíola Rainato, M.D, Suen, Vivian M.M., Ph.D, Marchini, Julio Sergio, Ph.D, Dutra de Oliveira, José Eduardo, Ph.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01-11-2009; [New York]: Elsevier Science Inc; Elsevier; Elsevier Limited
• Subjects: Acetic acid; Adult; Aged; Anemia; Area Under Curve; Bioavailability; Biological and medical sciences; blood chemistry; Brazil; Cell Fractionation; Cross-Over Studies; dehydrated cell fraction; dietary mineral supplements; dietary minerals; dosage; dose response; Dose-Response Relationship, Drug; Double-Blind Method; Edetic Acid - pharmacology; EDTA (chelating agent); Enterectomized patients; Erythrocytes; Feeding. Feeding behavior; Female; Ferremia; Ferrous Compounds - administration & dosage; Ferrous Compounds - blood; ferrous sulfate; Fundamental and applied biological sciences. Psychology; Gastroenterology and Hepatology; Humans; Ingestion; intestinal absorption; intestines; iron; Iron - administration & dosage; Iron - blood; Iron compounds; Male; Middle Aged; nutrient availability; nutrient deficiencies; Nutrient deficiency; nutritional status; patients; short bowel syndrome; Short Bowel Syndrome - blood; Short Bowel Syndrome - surgery; simulation models; Studies; Sulfates; temporal variation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Brazil; Enterectomized patients; Ferremia; Iron compounds; Human; Iron; Short bowel syndrome; Sulfates; Ingestion; Vertebrata; Mammalia; Intestinal malabsorption; Digestive diseases; Intestinal disease
• ISSN: 0899-9007; 1873-1244
• DOI: 10.1016/j.nut.2009.01.019

Abstract Objective Because short bowel syndrome is associated with iron deficiency, the objective of the present study was to monitor ferremia after the ingestion of different iron compounds and doses in enterectomized patients. Methods This was a randomized, double-blind, cross-over study conducted in 13 patients of both sexes in the metabolic unit of Hospital das Clínicas de Faculdade de Medicina de Ribeirão Preto-Universídade de São Paulo and was divided into two stages. Three different iron compounds, ferrous sulfate (FS), sodium iron ethylenediaminetetra-acetic acid (EDTA), and dehydrated cell fraction (DCF), were studied. The patients were randomly assigned to one of four groups receiving high-dose DCF (120 mg) and low-dose DCF (5 mg) and the two iron compounds. The subjects ( n = 7) receiving high-dose DCF participated in 2 test days. All patients receiving the physiologic dose (low-dose DCF, n = 6) participated in 3 test days with a 1-mo interval between compounds. After an 8-h fast, blood samples were collected at 0.25, 0.5, 1, and 2 h. Serum iron curve and the sum of the area under the curve were calculated and adjusted according to a mixed-effect linear model ( P < 0.05). Results Serum FS levels were higher in the 120-mg group compared with the others ( P < 0.005). The mean areas under the curve for FS and EDTA at the doses of 120 and 5 mg of elemental iron were 238, 224, 177, and 153 μg/dL, respectively. The mean area under the curve for DCF was 165 μg/dL, with no significant difference between groups. Conclusion Regardless of dose, FS was the compound that resulted in higher ferremia compared with the other doses and compounds.