Fungal metabolites. XVIII: New membrane-modifying peptides, trichorozins I-IV, from the fungus Trichoderma harzianum

• Published in: Chemical & pharmaceutical bulletin Vol. 43; no. 3; pp. 392 - 397
• Main Authors: IIDA, A, SANEKATA, M, WADA, S.-I, FUJITA, T, TANAKA, H, ENOKI, A, FUSE, G, KANAI, M, ASAMI, K
• Format: Journal Article
• Language: English
• Published: Tokyo Maruzen 1995
• Subjects: Amino Acid Sequence; Aminoacids, peptides. Hormones. Neuropeptides; Analytical, structural and metabolic biochemistry; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; Fungal Proteins - biosynthesis; Fungal Proteins - chemistry; Fungal Proteins - pharmacology; Ion Channels - drug effects; Lipid Bilayers; Membrane Proteins - drug effects; Molecular Sequence Data; Oligopeptides - biosynthesis; Oligopeptides - chemistry; Oligopeptides - pharmacology; Proteins; Spectrometry, Mass, Fast Atom Bombardment; Trichoderma - chemistry; Trichoderma - metabolism; Trichoderma harzianum; Aminoalcohol; Oligopeptides; Peptides; Metabolite; Ionic channel; Amphiphilic compound; Fungi; Trichoderma harzianum; Plant origin; Isolation; Fungi Imperfecti; Thallophyta; Structural analysis; Conidia
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.43.392

New membrane-modifying peptides, trichorozins I-IV, have been isolated from conidia of the fungus Trichoderma harzianum. Their amino acid sequences were clearly determined by spectrometric methods and, furthermore, they were synthesized by the solution-phase method. Trichorozins are a family of the class of peptaibols and are composed of 11 residues including an amino alcohol. Trichorozins exhibited voltage-dependent ion channel-like activity in lipid bilayers.