Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation

Coenzyme Q10 (CoQ10) is the only lipid‐soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration. A deficiency in either its bioava...

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Published in:	Nutrition reviews Vol. 71; no. 3; pp. 180 - 188
Main Authors:	Potgieter, Marnie, Pretorius, Etheresia, Pepper, Michael S
Format:	Journal Article
Language:	English
Published:	Hoboken, NJ Wiley 01-03-2013 Oxford University Press
Subjects:	antioxidant Biological and medical sciences Biosynthesis Cells CoQ10 CoQ10 deficiency Dietary Supplements Enzymes Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use hypercholesterolemia Hypercholesterolemia - drug therapy Mutation statins supplementation Ubiquinone - analogs & derivatives Ubiquinone - deficiency Ubiquinone - physiology Ubiquinone - therapeutic use Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin deficiency Secondary Deficiency CoQ10 Metabolic diseases Lipids Hyperlipoproteinemia Lipoprotein Antioxidant Cholesterol Feeding Coenzyme Hypercholesterolemia CoQ10 deficiency statins Supplementation Dyslipemia
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Abstract	Coenzyme Q10 (CoQ10) is the only lipid‐soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration. A deficiency in either its bioavailability or its biosynthesis can lead to one of several disease states. Primary deficiency has been well described and results from mutations in genes involved in CoQ10 biosynthesis. Secondary deficiency may be linked to hydroxymethylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors (statins), which are used for the treatment of hypercholesterolemia. Dietary contributions of CoQ10 are very small, but supplementation is effective in increasing plasma CoQ10 levels. It has been clearly demonstrated that treatment with CoQ10 is effective in numerous disorders and deficiency states and that supplementation has a favorable outcome. However, CoQ10 is not routinely prescribed in clinical practice. This review explores primary as well as statin‐induced secondary deficiency and provides an overview of the benefits of CoQ10 supplementation.
AbstractList	Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration. A deficiency in either its bioavailability or its biosynthesis can lead to one of several disease states. Primary deficiency has been well described and results from mutations in genes involved in CoQ10 biosynthesis. Secondary deficiency may be linked to hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), which are used for the treatment of hypercholesterolemia. Dietary contributions of CoQ10 are very small, but supplementation is effective in increasing plasma CoQ10 levels. It has been clearly demonstrated that treatment with CoQ10 is effective in numerous disorders and deficiency states and that supplementation has a favorable outcome. However, CoQ10 is not routinely prescribed in clinical practice. This review explores primary as well as statin-induced secondary deficiency and provides an overview of the benefits of CoQ10 supplementation. Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known for its role in the electron transport chain in mitochondrial membranes during aerobic cellular respiration. A deficiency in either its bioavailability or its biosynthesis can lead to one of several disease states. Primary deficiency has been well described and results from mutations in genes involved in CoQ10 biosynthesis. Secondary deficiency may be linked to hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), which are used for the treatment of hypercholesterolemia. Dietary contributions of CoQ10 are very small, but supplementation is effective in increasing plasma CoQ10 levels. It has been clearly demonstrated that treatment with CoQ10 is effective in numerous disorders and deficiency states and that supplementation has a favorable outcome. However, CoQ10 is not routinely prescribed in clinical practice. This review explores primary as well as statin-induced secondary deficiency and provides an overview of the benefits of CoQ10 supplementation. [PUBLICATION ABSTRACT]
Author	Potgieter, Marnie Pretorius, Etheresia Pepper, Michael S
Author_xml	– sequence: 1 givenname: Marnie surname: Potgieter fullname: Potgieter, Marnie organization: University of Pretoria – sequence: 2 givenname: Etheresia surname: Pretorius fullname: Pretorius, Etheresia organization: University of Pretoria – sequence: 3 givenname: Michael S surname: Pepper fullname: Pepper, Michael S organization: University of Pretoria
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Keywords	Secondary Deficiency CoQ10 Metabolic diseases Lipids Hyperlipoproteinemia Lipoprotein Antioxidant Cholesterol Feeding Coenzyme Hypercholesterolemia CoQ10 deficiency statins Supplementation Dyslipemia
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Snippet	Coenzyme Q10 (CoQ10) is the only lipid‐soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known... Coenzyme Q10 (CoQ10) is the only lipid-soluble antioxidant that animal cells synthesize de novo. It is found in cell membranes and is particularly well known...
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SubjectTerms	antioxidant Biological and medical sciences Biosynthesis Cells CoQ10 CoQ10 deficiency Dietary Supplements Enzymes Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use hypercholesterolemia Hypercholesterolemia - drug therapy Mutation statins supplementation Ubiquinone - analogs & derivatives Ubiquinone - deficiency Ubiquinone - physiology Ubiquinone - therapeutic use Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin deficiency
Title	Primary and secondary coenzyme Q10 deficiency: the role of therapeutic supplementation
URI	https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnure.12011 https://www.ncbi.nlm.nih.gov/pubmed/23452285 https://www.proquest.com/docview/1314593688 https://search.proquest.com/docview/1314710601
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