E2-RING Expansion of the NEDD8 Cascade Confers Specificity to Cullin Modification

Ubiquitin and ubiquitin-like proteins (UBLs) are directed to targets by cascades of E1, E2, and E3 enzymes. The largest ubiquitin E3 subclass consists of cullin-RING ligases (CRLs), which contain one each of several cullins (CUL1, -2, -3, -4, or -5) and RING proteins (RBX1 or -2). CRLs are activated...

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Bibliographic Details
Published in:	Molecular cell Vol. 33; no. 4; pp. 483 - 495
Main Authors:	Huang, Danny T., Ayrault, Olivier, Hunt, Harold W., Taherbhoy, Asad M., Duda, David M., Scott, Daniel C., Borg, Laura A., Neale, Geoffrey, Murray, Peter J., Roussel, Martine F., Schulman, Brenda A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 27-02-2009
Subjects:	Amino Acid Sequence Animals BASIC BIOLOGICAL SCIENCES Binding Sites Cells, Cultured Cullin Proteins - metabolism ENZYMES FLEXIBILITY FUNCTIONALS GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE IN VITRO IN VIVO LIGASES LYSINE Mice Models, Molecular MODIFICATIONS Molecular Sequence Data NIH 3T3 Cells PLASTICITY Protein Conformation Protein Folding PROTEINS SPECIFICITY TARGETS Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitins - chemistry Ubiquitins - metabolism PROTEINS
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