Low-dose aspirin prevents age-related endothelial dysfunction in a mouse model of physiological aging

The age-related impairment of endothelium-dependent vasodilatation contributes to increased cardiovascular risk in the elderly. For primary and secondary prevention, aspirin can reduce the incidence of cardiovascular events in this patient population. The present work evaluated the effect of low-dos...

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Bibliographic Details
Published in:	American journal of physiology. Heart and circulatory physiology Vol. 294; no. 4; p. H1562
Main Authors:	Bulckaen, Hélène, Prévost, Gaétan, Boulanger, Eric, Robitaille, Géraldine, Roquet, Valérie, Gaxatte, Cédric, Garçon, Guillaume, Corman, Bruno, Gosset, Pierre, Shirali, Pirouz, Creusy, Colette, Puisieux, François
Format:	Journal Article
Language:	English
Published:	United States 01-04-2008
Subjects:	Acetylcholine - pharmacology Age Factors Aging - metabolism Aging - pathology Animals Antioxidants - administration & dosage Aorta - drug effects Aorta - metabolism Aorta - physiopathology Aspirin - administration & dosage Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - prevention & control Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dose-Response Relationship, Drug Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - physiopathology Male Malondialdehyde - metabolism Mice Mice, Inbred C57BL Models, Animal Oxidative Stress - drug effects Phenylephrine - pharmacology Vasoconstrictor Agents - pharmacology Vasodilation - drug effects Vasodilator Agents - pharmacology
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