Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation

Cryoablation of a solitary tumor mass releases intact tumor antigens and can induce protective antitumor immunity but has limited efficacy in the treatment of established metastatic cancer. Cyclophosphamide (Cy), an anticancer drug, selectively depletes regulatory T cells (T(reg)s) and attenuates su...

Full description

Saved in:

Bibliographic Details
Published in:	The Journal of pharmacology and experimental therapeutics Vol. 330; no. 2; p. 596
Main Authors:	Levy, Moshe Yair, Sidana, Abhinav, Chowdhury, Wasim H, Solomon, Steven B, Drake, Charles G, Rodriguez, Ronald, Fuchs, Ephraim J
Format:	Journal Article
Language:	English
Published:	United States 01-08-2009
Subjects:	Animals Antineoplastic Agents, Alkylating - administration & dosage CD8-Positive T-Lymphocytes - transplantation Cell Line, Tumor Cryosurgery - methods Cyclophosphamide - administration & dosage Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - immunology Female Injections, Intravenous Injections, Subcutaneous Mice Mice, Inbred BALB C Neoplasms, Experimental - drug therapy Neoplasms, Experimental - immunology Neoplasms, Experimental - secondary Neoplasms, Experimental - surgery Random Allocation
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!