Comparative antimutagenic and anticlastogenic effects of green tea and black tea: a review

• Published in: Mutation Research-Reviews in Mutation Research Vol. 512; no. 1; pp. 37 - 65
• Main Authors: Gupta, S, Saha, B, Giri, A.K
• Format: Book Review Journal Article
• Language: English
• Published: Lausanne Elsevier B.V 01-09-2002; Amsterdam Elsevier Science; New York, NY
• Subjects: Animals; Anticarcinogenic Agents - pharmacology; Anticlastogenicity; Antimutagenic Agents - pharmacology; Antimutagenicity; Biflavonoids; Biological and medical sciences; Black tea; Catechin - pharmacology; Catechins; Cells, Cultured - drug effects; Cricetinae; Cricetulus; DNA Adducts; DNA damage; Escherichia coli - drug effects; Fermentation; Flavonoids; Food toxicology; Genes, Bacterial - drug effects; Genes, Dominant - drug effects; Genes, Lethal - drug effects; Green tea; Humans; Medical sciences; Mice; Mutagenicity Tests; Mutagens - pharmacology; Phenols - pharmacology; Polymers - pharmacology; Rats; Salmonella typhimurium - drug effects; Tea - classification; Tea polyphenols; Theaflavins; Thearubigins; Toxicology; MNU, N-methylnitrosourea; IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; TSNAs, tobacco-specific nitrosamines; EGC, (−)-epigallocatechin; MNNG, N-methyl- N′-nitro- N′-nitrosoguanidine; NNK, 4-( N-methyl- N- n-trosamino)-1-(3-pyridyl)-1-butanone; DCNB, 3,4-dichloronitrobenzene; 2AA, 2-aminoanthracene; Black tea; B[a]P diol epoxide, 7β,8α-dihydroxy-9α,10α-epoxi-7,8,9,10-tetra-hydrobenzo[a]pyrene; PQ, paraquat; UDS, unscheduled DNA synthesis; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; C, (+)-catechin; DBE, 1,2-dibromoethane; HCA, heterocyclic amine; AOM, azoxymethane; MROD, methoxyresorufin O-demethylase; NPD, 4-nitro- o-phenylenediamine; Antimutagenicity; 2NP, 2-nitropropane; Theaflavins; Trp-P-1, 1,4-dimethyl-5H-pyrido[4,3-b]indole; DMBA, 7,12-dimethylbenz[a]anthracene; TF2B, theaflavin monogallate B; 2AF, 2-aminofluorene; 2dG, 2′-deoxyguanosine; ESR, electron spin resonance; Trp-P-2, 3-amino-1-methyl-5H-pyrido[4,3-b]indole; N–OH-Trp-P-2, 3-hydroxy amino Trp-P-2; tBuOOH, tert-butyl hydroperoxide; GC, (+)-gallocatechin; DEN, N-diethyl-nitrosamine; DMPO, 5,5-dimethyl-1-pyrroline N-oxide; SA, sodium azide; GTEC, green tea epicatechin compounds; 4,8-DiMeIQx, 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline; WEGT, water extract of green tea; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; TF2A, theaflavin monogallate A; CDNB, 1-chloro-2,4-dinitrobenzene; GTP, green tea polyphenols; EC, (−)-epicatechin; GTE, green tea extract; EGCG, (−)-epigallocatechin-3-gallate; DNA damage; 13C, indole-3-carbinol; TF1, theaflavin; MTCCA, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; Catechins; Glu-P-1, 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole; TF3, theaflavin digallate; TR, thearubigins; GTC, green tea catechins; 9AA, 9-aminoacridine; CP, cyclophosphamide; PCOOH, phosphatidylcholine hydroperoxide; NDMA, N-nitrosodimethylamine; CH, cumine hydroperoxide; ECG, (−)-epicatechin-3-gallate; WET, water extract of tea; HAA, heterocyclic aromatic amines; Green tea; TFMG, theaflavin monogallate; TFDG, theaflavin digallate; Anticlastogenicity; AFB 1, aflatoxin B 1; TF, theaflavins; ABP, 4-aminobiphenyl; DN, danthron; Thearubigins; 4NQO, 4-nitroquinolin 1-oxide; EMS, ethylmethanesulfonate; SaA, sarcophytol A; PHA, phytohaemagglutinin; DMH, 1,2-dimethylhydrazine; 6TG, 6-thioguanine; Tea polyphenols; TPA, 12- O-tetradecanoyl phorbol-13-acetate; MU, methylurea; B[a]P, benzo[a]pyrene; MMC, mitomycin C; Polyphenol; Literature; Toxicity; Antimutagen; Genotoxicity; Review; Mutation; Comparative study
• ISSN: 1383-5742; 0027-5107; 1388-2139
• DOI: 10.1016/S1383-5742(02)00024-8

Tea is the most popular beverage next to water, consumed by over two-thirds of the world’s population. It is processed in different ways in different parts of the world to give green, black or oolong tea. Experimental studies have demonstrated the significant antimutagenic and anticlastogenic effects of both green and black tea and its polyphenols in multiple mutational assays. In the present review, we have attempted to evaluate and update the comparative antimutagenic and anticlastogenic effects of green tea, black tea and their polyphenols in different test systems, based on available literature. Existing reports have suggested that the protective effects of black tea is as good as green tea, however, more studies on black tea and its polyphenols are needed before a final conclusion can be made.