Fucoidan from Undaria pinnatifida Induces Apoptosis in A549 Human Lung Carcinoma Cells

Fucoidan, a sulfated polysaccharide, has various biological activities, such as anticancer, antiangiogenic and antiinflammatory effects; however, the mechanisms of action of fucoidan on anticancer activity have not been fully elucidated. The anticancer effects of fucoidan from Undaria pinnatifida on...

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Bibliographic Details
Published in:	Phytotherapy research Vol. 25; no. 7; pp. 1082 - 1086
Main Authors:	Boo, Hye-Jin, Hyun, Jae-Hee, Kim, Sang-Cheol, Kang, Jung-Il, Kim, Min-Kyoung, Kim, Sun-Yeou, Cho, Heeyeong, Yoo, Eun-Sook, Kang, Hee-Kyoung
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-07-2011 Wiley
Subjects:	1-Phosphatidylinositol 3-kinase A549 AKT protein Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Bax protein Bcl-2 protein Biological and medical sciences Caspase-3 Caspase-9 caspases Cell Line, Tumor Chromatin Condensation Extracellular signal-regulated kinase fucoidan General pharmacology Humans Lung cancer Lung carcinoma Lung Neoplasms - metabolism Lung Neoplasms - pathology MAP kinase Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytotherapy PI3K/Akt Poly(ADP-ribose) polymerase Polysaccharides Polysaccharides - pharmacology Undaria - chemistry Undaria pinnatifida A549 Bronchopulmonary carcinoma Bronchopulmonary Medicinal plant PI3K/Akt Heterokontophyta Undaria pinnatifida Bronchus disease Tumor cell Phaeophyceae Human Lung disease Enzyme Respiratory disease Pharmacognosy Algae Transferases Akt protein kinase Caspase Mitogen-activated protein kinase MAP kinase Malignant tumor Edible alga Peptidases Cell death Plant origin Hydrolases Polysaccharide caspases Cancer Apoptosis
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