PLASMA LEVELS AND URINARY EXCRETION OF BATROXOBIN AND ITS DEFIBRINOGENATING EFFECTS IN VARIOUS ANIMAL SPECIES

• Published in: Journal of toxicological sciences Vol. 11; no. 2; pp. 135 - 143
• Main Authors: SUGAI, Ken-ichi, IMAMURA, Yasushi, MIHASHI, Susumu, OHBA, Mitsuoki, KUNIKANE, Kazutoshi, MORI, Noboru, BABA, Shigeo
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 1986; Japan Science and Technology Agency
• Subjects: animal experiment; Animals; Batroxobin - metabolism; Batroxobin - pharmacology; Dogs; Fibrinogen - analysis; Guinea Pigs; Half-Life; Macaca fascicularis; Male; Mice; Mice, Inbred Strains; Peptide Hydrolases - metabolism; Rabbits; Rats; Rats, Inbred Strains; Species Specificity
• ISSN: 0388-1350; 1880-3989
• DOI: 10.2131/jts.11.135

The plasma levels and urinary excretion of batroxobin administered to 6 species of animals were examined by an enzyme immunoassay method. Defibrinogenating effect of batroxobin was also studied in those species. The plasma levels of immunoreactive batroxobin disappeared exponentially in all the animals and differences in half-life were observed to occur according to species. The elimination half-life of immunoreactive batroxobin in the plasma was the largest in dogs, followed by rats, monkeys, guinea pigs, mice and rabbits. The extent of the defibrinogenating effect was also noted to vary according to the species, being greatest in dogs and then monkeys, mice, rats, guinea pigs and rabbits. Following the continuous infusion of batroxobin into dogs, its level in the plasma remained high over a considerable period of time and the defibrinogenating effect lasted in corresponding to its plasma level. The urinary excretion of immunoreactive batroxobin was quite small in these species, being 0.2-1.9% of the original dose.