LINE-1 methylation difference between ameloblastoma and keratocystic odontogenic tumor
Oral Diseases (2010) 16, 286–291 Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element‐1 (LINE‐1 or L1) meth...
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| Published in: | Oral diseases Vol. 16; no. 3; pp. 286 - 291 |
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Blackwell Publishing Ltd
01-04-2010
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| Abstract | Oral Diseases (2010) 16, 286–291
Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element‐1 (LINE‐1 or L1) methylation status between ameloblastoma and KCOT.
Materials and methods: We studied the methylation levels of the long interspersed nucleotide element‐1 (LINE‐1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE‐1 (COBRALINE‐1) was performed to measure LINE‐1 methylation levels.
Results: The LINE‐1 methylation level in KCOT (53.16 ± 12.03%) was higher than that in ameloblastoma (36.90 ± 16.52%), with a statistical significance of P = 0.001. The ranges of LINE‐1 methylation of both lesions were not associated with either age or sex.
Conclusion: We found LINE‐1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. |
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| AbstractList | Oral Diseases (2010) 16, 286-291Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element-1 (LINE-1 or L1) methylation status between ameloblastoma and KCOT.Materials and methods: We studied the methylation levels of the long interspersed nucleotide element-1 (LINE-1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE-1 (COBRALINE-1) was performed to measure LINE-1 methylation levels.Results: The LINE-1 methylation level in KCOT (53.16 c 12.03%) was higher than that in ameloblastoma (36.90 c 16.52%), with a statistical significance of P = 0.001. The ranges of LINE-1 methylation of both lesions were not associated with either age or sex.Conclusion: We found LINE-1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. Oral Diseases (2010) 16, 286–291 Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element‐1 (LINE‐1 or L1) methylation status between ameloblastoma and KCOT. Materials and methods: We studied the methylation levels of the long interspersed nucleotide element‐1 (LINE‐1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE‐1 (COBRALINE‐1) was performed to measure LINE‐1 methylation levels. Results: The LINE‐1 methylation level in KCOT (53.16 ± 12.03%) was higher than that in ameloblastoma (36.90 ± 16.52%), with a statistical significance of P = 0.001. The ranges of LINE‐1 methylation of both lesions were not associated with either age or sex. Conclusion: We found LINE‐1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. OBJECTIVEGlobal hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element-1 (LINE-1 or L1) methylation status between ameloblastoma and KCOT.MATERIALS AND METHODSWe studied the methylation levels of the long interspersed nucleotide element-1 (LINE-1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE-1 (COBRALINE-1) was performed to measure LINE-1 methylation levels.RESULTSThe LINE-1 methylation level in KCOT (53.16 +/- 12.03%) was higher than that in ameloblastoma (36.90 +/- 16.52%), with a statistical significance of P = 0.001. The ranges of LINE-1 methylation of both lesions were not associated with either age or sex.CONCLUSIONWe found LINE-1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element-1 (LINE-1 or L1) methylation status between ameloblastoma and KCOT. We studied the methylation levels of the long interspersed nucleotide element-1 (LINE-1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE-1 (COBRALINE-1) was performed to measure LINE-1 methylation levels. The LINE-1 methylation level in KCOT (53.16 +/- 12.03%) was higher than that in ameloblastoma (36.90 +/- 16.52%), with a statistical significance of P = 0.001. The ranges of LINE-1 methylation of both lesions were not associated with either age or sex. We found LINE-1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. Oral Diseases (2010) 16 , 286–291 Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same tissue in origin. Here, we investigated long interspersed nuclear element‐1 (LINE‐1 or L1) methylation status between ameloblastoma and KCOT. Materials and methods: We studied the methylation levels of the long interspersed nucleotide element‐1 (LINE‐1) in ameloblastoma and KCOT. After collecting ameloblastoma cells and epithelium lining cells of KCOT by laser capture microdissection from paraffin embedded tissue, combined bisulfite restriction analysis of LINE‐1 (COBRALINE‐1) was performed to measure LINE‐1 methylation levels. Results: The LINE‐1 methylation level in KCOT (53.16 ± 12.03%) was higher than that in ameloblastoma (36.90 ± 16.52%), with a statistical significance of P = 0.001. The ranges of LINE‐1 methylation of both lesions were not associated with either age or sex. Conclusion: We found LINE‐1 hypomethylation levels between ameloblastoma and KCOT are different. Therefore, global methylations between these tumors are processed differently. |
| Author | Kitkumthorn, N Mutirangura, A |
| Author_xml | – sequence: 1 givenname: N surname: Kitkumthorn fullname: Kitkumthorn, N organization: Department of Oral Pathology, Faculty of Dentistry, Mahidol University, Bangkok – sequence: 2 givenname: A surname: Mutirangura fullname: Mutirangura, A organization: Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand |
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| Snippet | Oral Diseases (2010) 16, 286–291
Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and... Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses the same... Oral Diseases (2010) 16 , 286–291 Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and... OBJECTIVEGlobal hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and ameloblastoma are different tumors but posses... Oral Diseases (2010) 16, 286-291Objective: Global hypomethylation is a common epigenetic event in cancer. Keratocystic odontogenic tumor (KCOT) and... |
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| SubjectTerms | Adult Aged Aged, 80 and over ameloblastoma Ameloblastoma - chemistry Ameloblastoma - genetics Cell Transformation, Neoplastic - genetics Child COBRALINE-1 Dentistry DNA Methylation DNA, Neoplasm - analysis Female Humans Jaw Neoplasms - chemistry Jaw Neoplasms - genetics Keratins keratocystic odontogenic tumor LINE-1 Long Interspersed Nucleotide Elements - genetics Male methylation level Middle Aged Odontogenic Tumors - chemistry Odontogenic Tumors - genetics Promoter Regions, Genetic Restriction Mapping - methods Young Adult |
| Title | LINE-1 methylation difference between ameloblastoma and keratocystic odontogenic tumor |
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