Autoregulation of the Rsc4 Tandem Bromodomain by Gcn5 Acetylation

An important issue for chromatin remodeling complexes is how their bromodomains recognize particular acetylated lysine residues in histones. The Rsc4 subunit of the yeast remodeler RSC contains an essential tandem bromodomain (TBD) that binds acetylated K14 of histone H3 (H3K14ac). We report a serie...

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Bibliographic Details
Published in:	Molecular cell Vol. 27; no. 5; pp. 817 - 828
Main Authors:	VanDemark, Andrew P., Kasten, Margaret M., Ferris, Elliott, Heroux, Annie, Hill, Christopher P., Cairns, Bradley R.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 07-09-2007
Subjects:	Acetylation Amino Acid Sequence Chromatin Assembly and Disassembly - physiology Crystallography, X-Ray DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Histone Acetyltransferases - chemistry Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Histones - chemistry Histones - metabolism Models, Genetic Models, Molecular Molecular Sequence Data Phosphorylation Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Transcription Factors - chemistry Transcription Factors - metabolism DNA
Online Access:	Get full text
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