Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis

• Published in: Biology (Basel, Switzerland) Vol. 10; no. 2; p. 116
• Main Authors: Perez-Dominguez, Francisco, Carrillo-Beltrán, Diego, Blanco, Rancés, Muñoz, Juan P, León-Cruz, Grettell, Corvalan, Alejandro H, Urzúa, Ulises, Calaf, Gloria M, Aguayo, Francisco
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04-02-2021; MDPI
• Subjects: Adapter proteins; Antioxidants; Apoptosis; Binding sites; Carcinogenesis; Cell adhesion & migration; Cervical cancer; Chronic obstructive pulmonary disease; Human papillomavirus; Kinases; Lung cancer; Lymphocytes B; Lymphoma; NF-κB protein; Oxidative stress; Prokaryotes; Review; Transcription; Transcription factors; pirin; epithelial; cancer
• ISSN: 2079-7737; 2079-7737
• DOI: 10.3390/biology10020116

Pirin is an oxidative stress (OS) sensor belonging to the functionally diverse cupin superfamily of proteins. Pirin is a suggested quercetinase and transcriptional activator of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway. Its biological role in cancer development remains a novel area of study. This review presents accumulating evidence on the contribution of Pirin in epithelial cancers, involved signaling pathways, and as a suggested therapeutic target. Finally, we propose a model in which Pirin is upregulated by physical, chemical or biological factors involved in OS and cancer development.