A novel β-catenin signaling pathway activated by IL-1β leads to the onset of epithelial–mesenchymal transition in breast cancer cells

Highlights • IL-1β activates β-catenin signaling to elicit malignancy in breast cancer cells. • IL-1β inhibits GSK3β activity through Akt. • IL-1β/β-catenin signaling leads to the onset of epithelial–mesenchyma transition.

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Bibliographic Details
Published in:	Cancer letters Vol. 354; no. 1; pp. 164 - 171
Main Authors:	Perez-Yepez, Eloy Andres, Ayala-Sumuano, Jorge-Tonatiuh, Lezama, Ruth, Meza, Isaura
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 01-11-2014
Subjects:	Active Transport, Cell Nucleus beta Catenin - metabolism Breast cancer cell Breast Neoplasms - metabolism Cell Line, Tumor Cell Movement Cell Proliferation Epithelial-Mesenchymal Transition Female Gene Expression Regulation, Neoplastic Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Hematology, Oncology and Palliative Medicine Humans IL-1RI/β-catenin signaling IL-1β stimulation Interleukin-1beta - metabolism Invasiveness Neoplasm Invasiveness Phenotype Polyunsaturated Alkamides - chemistry Proto-Oncogene Proteins c-akt - metabolism Signal Transduction MFA Breast cancer cell IL-1β stimulation 2-methyl-2′-F-anandamide IL-1RI/β-catenin signaling Invasiveness
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Summary:	Highlights • IL-1β activates β-catenin signaling to elicit malignancy in breast cancer cells. • IL-1β inhibits GSK3β activity through Akt. • IL-1β/β-catenin signaling leads to the onset of epithelial–mesenchyma transition.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.015