Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

The role of hepatobiliary transporters in drug-induced liver injury remains poorly understood. Various in vivo and in vitro biological approaches are currently used for studying hepatic transporters; however, appropriate localization and functional activity of these transporters are essential for no...

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Bibliographic Details

Published in:	Toxicological Sciences Vol. 145; no. 1; pp. 157 - 168
Main Authors:	Bachour-El Azzi, Pamela, Sharanek, Ahmad, Burban, Audrey, Li, Ruoya, Guével, Rémy Le, Abdel-Razzak, Ziad, Stieger, Bruno, Guguen-Guillouzo, Christiane, Guillouzo, André
Format:	Journal Article
Language:	English
Published:	United States Oxford University Press (OUP) 01-05-2015 Oxford University Press
Subjects:	Cell Line Hepatocytes - metabolism Humans Life Sciences Membrane Transport Proteins - metabolism Transporters in HepaRG and Primary Human Hepatocytes hepatobiliary transporters human hepatocytes transporter activity HepaRG hepatocytes membrane localization
Online Access:	Get full text
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