Comparison of next generation sequencing, droplet digital PCR, and quantitative real-time PCR for the earlier detection and quantification of HPV in HPV-positive oropharyngeal cancer

•HPV DNA is often detected by qualitative PCR, real time PCR, and other technologies including NGS and ddPCR are being explored.•NGS and ddPCR in plasma and NGS in oral rinse have good sensitivity for HPV16-OPC.•HPV levels detected in plasma by NGS may mirror the clinical course of HPV-positive head...

Full description

Saved in:

Bibliographic Details
Published in:	Oral oncology Vol. 128; p. 105805
Main Authors:	Mattox, Austin K., D'Souza, Gypsyamber, Khan, Zubair, Allen, Hailey, Henson, Stephanie, Seiwert, Tanguy Y., Koch, Wayne, Pardoll, Drew M., Fakhry, Carole
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-05-2022
Subjects:	Alphapapillomavirus - genetics ddPCR DNA Early Detection of Cancer Head and neck cancer High-Throughput Nucleotide Sequencing HPV Humans Liquid biopsy Neoplasm Recurrence, Local Next generation sequencing Oropharyngeal cancer Oropharyngeal Neoplasms Papillomaviridae - genetics Papillomavirus Infections - complications Papillomavirus Infections - diagnosis Quantitative real-time PCR Real-Time Polymerase Chain Reaction ddPCR Quantitative real-time PCR Oropharyngeal cancer Liquid biopsy Head and neck cancer Next generation sequencing HPV
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!