Cryptococcus neoformans MET5 Gene is not Essential for Virulence in the Silkworm Infection Model

The involvement of the MET5 gene in virulence of Cryptococcus neoformans was examined using the silkworm Bombyx mori infection model. In the virulence assay, the met5Δ mutant showed virulence not significantly different from the wild-type strain, suggesting that the MET5 gene is not essential for fu...

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Bibliographic Details
Published in:	Medical Mycology Journal Vol. 63; no. 3; pp. 77 - 80
Main Authors:	Nguyen, Phuong-Thao, Nguyen, Ngoc-Hung, Kang, Ying-Qian, Shimizu, Kiminori
Format:	Journal Article
Language:	English
Published:	Tokyo The Japanese Society for Medical Mycology 2022 Japan Science and Technology Agency
Subjects:	antifungal Bombyx mori Cryptococcus neoformans Hemolymph Mutants sulfur assimilation pathway Survival Virulence
Online Access:	Get full text
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Summary:	The involvement of the MET5 gene in virulence of Cryptococcus neoformans was examined using the silkworm Bombyx mori infection model. In the virulence assay, the met5Δ mutant showed virulence not significantly different from the wild-type strain, suggesting that the MET5 gene is not essential for full virulence of C. neoformans. The effect of silkworm hemolymph on the survival of the met5Δ mutant was also tested. The C. neoformans met5Δ strain incubated in the silkworm hemolymph for five days remained viable, suggesting that silkworm hemolymph supports survival of the met5Δ strain.
ISSN:	2185-6486 2186-165X
DOI:	10.3314/mmj.21-00023