Podosomes in adhesion, migration, mechanosensing and matrix remodeling

Cells use various actin‐based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin cytoskeletal structures that form in motile cells and that mediate adhesion to substrate, migration, and other specialized functions such as transmi...

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Published in:	Cytoskeleton (Hoboken, N.J.) Vol. 70; no. 10; pp. 572 - 589
Main Authors:	Schachtner, Hannah, Calaminus, Simon D. J., Thomas, Steven G., Machesky, Laura M.
Format:	Journal Article
Language:	English
Published:	United States Blackwell Publishing Ltd 01-10-2013 Wiley Subscription Services, Inc
Subjects:	actin Actin Cytoskeleton - metabolism adhesion Animals Cell Adhesion Cell Movement Extracellular Matrix - metabolism Humans Mechanotransduction, Cellular migration podosome Signal Transduction podosome migration actin adhesion
Online Access:	Get full text
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Abstract	Cells use various actin‐based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin cytoskeletal structures that form in motile cells and that mediate adhesion to substrate, migration, and other specialized functions such as transmigration through cell and matrix barriers. The podosome is a unique and interesting entity, which appears in the light microscope as an individual punctum, but is linked to other podosomes like a node on a network of the underlying cytoskeleton. Here, we discuss the signals that control podosome assembly and dynamics in different cell types and the actin organising proteins that regulate both the inner actin core and integrin‐rich surrounding ring structures. We review the structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage. We also discuss the emerging idea that podosomes can sense matrix stiffness and enable cells to respond to their environment. © 2013 Wiley Periodicals, Inc.
AbstractList	Cells use various actin-based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin cytoskeletal structures that form in motile cells and that mediate adhesion to substrate, migration, and other specialized functions such as transmigration through cell and matrix barriers. The podosome is a unique and interesting entity, which appears in the light microscope as an individual punctum, but is linked to other podosomes like a node on a network of the underlying cytoskeleton. Here, we discuss the signals that control podosome assembly and dynamics in different cell types and the actin organising proteins that regulate both the inner actin core and integrin-rich surrounding ring structures. We review the structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage. We also discuss the emerging idea that podosomes can sense matrix stiffness and enable cells to respond to their environment. Cells use various actin‐based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin cytoskeletal structures that form in motile cells and that mediate adhesion to substrate, migration, and other specialized functions such as transmigration through cell and matrix barriers. The podosome is a unique and interesting entity, which appears in the light microscope as an individual punctum, but is linked to other podosomes like a node on a network of the underlying cytoskeleton. Here, we discuss the signals that control podosome assembly and dynamics in different cell types and the actin organising proteins that regulate both the inner actin core and integrin‐rich surrounding ring structures. We review the structure and composition of podosomes and also their functions in various cell types of both myeloid and endothelial lineage. We also discuss the emerging idea that podosomes can sense matrix stiffness and enable cells to respond to their environment. © 2013 Wiley Periodicals, Inc.
Author	Schachtner, Hannah Calaminus, Simon D. J. Machesky, Laura M. Thomas, Steven G.
Author_xml	– sequence: 1 givenname: Hannah surname: Schachtner fullname: Schachtner, Hannah organization: CRUK Beatson Institute for Cancer Research and College of Medical, Veterinary and Life Sciences, Glasgow University, Garscube Campus, Switchback Rd., Bearsden, Glasgow, United Kingdom – sequence: 2 givenname: Simon D. J. surname: Calaminus fullname: Calaminus, Simon D. J. organization: Hull York Medical School, University of Hull, Hull, United Kingdom – sequence: 3 givenname: Steven G. surname: Thomas fullname: Thomas, Steven G. organization: Centre for Cardiovascular Sciences, Institute for Biomedical Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom – sequence: 4 givenname: Laura M. surname: Machesky fullname: Machesky, Laura M. email: l.machesky@beatson.gla.ac.uk organization: CRUK Beatson Institute for Cancer Research and College of Medical, Veterinary and Life Sciences, Glasgow University, Garscube Campus, Switchback Rd., Bearsden, Glasgow, United Kingdom
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23804547$$D View this record in MEDLINE/PubMed
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Snippet	Cells use various actin‐based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin... Cells use various actin-based motile structures to allow them to move across and through matrix of varying density and composition. Podosomes are actin...
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SubjectTerms	actin Actin Cytoskeleton - metabolism adhesion Animals Cell Adhesion Cell Movement Extracellular Matrix - metabolism Humans Mechanotransduction, Cellular migration podosome Signal Transduction
Title	Podosomes in adhesion, migration, mechanosensing and matrix remodeling
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