Granulocyte and Monocyte Adsorption Apheresis for Cutaneous Allergic Vasculitis

• Published in: Therapeutic apheresis and dialysis Vol. 10; no. 3; pp. 287 - 290
• Main Authors: Kanekura, Takuro, Yoshii, Noriko, Kawahara, Koichi, Maruyama, Ikuro, Kanzaki, Tamotsu
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01-06-2006
• Subjects: Adsorption apheresis; Allergic vasculitis; Blood Component Removal - methods; Female; Hemoperfusion - methods; Humans; Macrophage-1 Antigen - blood; Macrophage-1 Antigen - metabolism; Middle Aged; Monocytes - immunology; Neutrophils; Neutrophils - immunology; Treatment Outcome; Vasculitis, Leukocytoclastic, Cutaneous - therapy
• ISSN: 1744-9979; 1744-9987
• DOI: 10.1111/j.1744-9987.2006.00335.x

:  Cutaneous allergic vasculitis (CAV) is characterized clinically by purpuric patches with secondary ulcerations, and histologically by leukocytoclastic vasculitis with neutrophil infiltrates. Granulocyte and monocyte adsorption apheresis (GCAP) is an extracorporeal apheresis instrument using a column containing cellulose acetate beads designed to remove pathogenic granulocytes. Here we report our assessment of the efficacy of GCAP for recurrent leg ulcers in a 49‐year‐old woman with CAV. She underwent five GCAP treatments at one‐week intervals. In each treatment session, 1800 mL of blood was processed. Her leg ulcers responded well and her white blood cell and neutrophil counts and the expression level of CD11b/CD18, a marker for activated neutrophils, on her peripheral neutrophils were reduced from 7500/µL to 6500/µL, 4350/µL to 3315/µL, and 64.9 MFI (mean fluorescence intensity) to 27.0 MFI (normal controls: 10.5 ± 1.2 MFI) by GCAP, respectively. These results suggest that GCAP is useful for skin disorders with leucocytoclastic vasculitis.