TRPV4 and the Regulation of Vascular Tone
Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg,...
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| Published in: | Journal of cardiovascular pharmacology Vol. 61; no. 2; pp. 113 - 119 |
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| Format: | Journal Article |
| Language: | English |
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Hagerstown, MD
Lippincott Williams & Wilkins, Inc
01-02-2013
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| Abstract | Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place. |
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| AbstractList | Recent studies have introduced the importance of Transient Receptor Potential Vanilloid Subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (e.g. shear stress, cell swelling, and heat) and chemical (e.g. epoxyeicosatrienoic acids (EETs), endocanabinoids, 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation, TRPV4 channel interaction with other proteins including Transient Receptor Potential Channel 1 (TRPC1), small conductance (K
Ca
2.3) and large conductance (K
Ca
1.1) calcium-activated, potassium-selective channels and the importance of caveolin-rich domains for these interactions to take place. Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (K(Ca)2.3), and large conductance (K(Ca)1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place. Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4 channels are expressed in both endothelium and vascular smooth muscle cells and can be activated by numerous stimuli including mechanical (eg, shear stress, cell swelling, and heat) and chemical (eg, epoxyeicosatrienoic acids, endocannabinoids, and 4α-phorbol esters). In the brain, TRPV4 channels are primarily localized to astrocytic endfeet processes, which wrap around blood vessels. Thus, TRPV4 channels are strategically localized to sense hemodynamic changes and contribute to the regulation of vascular tone. TRPV4 channel activation leads to smooth muscle cell hyperpolarization and vasodilation. Here, we review recent findings on the cellular mechanisms underlying TRPV4-mediated vasodilation; TRPV4 channel interaction with other proteins including transient receptor potential channel 1, small conductance (KCa2.3), and large conductance (KCa1.1) calcium-activated potassium-selective channels; and the importance of caveolin-rich domains for these interactions to take place. |
| Author | Filosa, Jessica A Yao, Xiaoqiang Rath, Geraldine |
| AuthorAffiliation | Georgia Health Sciences University, Augusta, GA †Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China ‡Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium |
| AuthorAffiliation_xml | – name: Georgia Health Sciences University, Augusta, GA †Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China ‡Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium – name: 1 Georgia Health Sciences University, Augusta, Georgia, USA – name: 2 Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China – name: 3 Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium |
| Author_xml | – sequence: 1 givenname: Jessica surname: Filosa middlename: A fullname: Filosa, Jessica A organization: Georgia Health Sciences University, Augusta, GA †Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China ‡Pole of Pharmacology and Therapeutics (FATH), Institute of Experimental and Clinical Research (IREC), Université Catholique de Louvain, Brussels, Belgium – sequence: 2 givenname: Xiaoqiang surname: Yao fullname: Yao, Xiaoqiang – sequence: 3 givenname: Geraldine surname: Rath fullname: Rath, Geraldine |
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| Keywords | Vasomotricity TRPV4 vanilloid receptor TRPV4 Smooth muscle astrocytes In vitro vascular smooth muscle cells Vasodilation Endothelium |
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| Snippet | Recent studies have introduced the importance of transient receptor potential vanilloid subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4... Recent studies have introduced the importance of Transient Receptor Potential Vanilloid Subtype 4 (TRPV4) channels in the regulation of vascular tone. TRPV4... |
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| SubjectTerms | Animals Astrocytes - metabolism Biological and medical sciences Brain - physiology Cardiovascular system Caveolins - metabolism Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Hemodynamics Humans Medical sciences Myocytes, Smooth Muscle - metabolism Pharmacology. Drug treatments TRPV Cation Channels - metabolism Vasodilation - physiology |
| Title | TRPV4 and the Regulation of Vascular Tone |
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