The mitochondrial heat shock protein 60 (HSP60) is up-regulated in Onchocerca volvulus after the depletion of Wolbachia

Wolbachia, a genus of endosymbiotic bacteria of filarial worms, represent novel targets for anti-filarial therapy. The efficacy of compounds against Wolbachia has been evaluated using antiserum raised against the 60 kDa heat shock protein (HSP60) which binds specifically to this protein in both Wolb...

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Bibliographic Details
Published in:	Parasitology Vol. 135; no. 4; p. 529
Main Authors:	Pfarr, K M, Heider, U, Schmetz, C, Büttner, D W, Hoerauf, A
Format:	Journal Article
Language:	English
Published:	England 01-04-2008
Subjects:	Animals Anti-Bacterial Agents - therapeutic use Chaperonin 60 - biosynthesis Chaperonin 60 - genetics Doxycycline - therapeutic use Female Humans Immunohistochemistry Ivermectin - therapeutic use Male Microscopy, Electron Mitochondria - metabolism Onchocerca volvulus - genetics Onchocerca volvulus - metabolism Onchocerca volvulus - microbiology Onchocerciasis - drug therapy Onchocerciasis - microbiology Onchocerciasis - parasitology Reverse Transcriptase Polymerase Chain Reaction RNA, Helminth - genetics Symbiosis Transcription, Genetic Up-Regulation Wolbachia - drug effects Wolbachia - isolation & purification Wolbachia - metabolism
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