Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by a specific pattern of neuropathological changes, including extracellular amyloid β (Aβ) deposits, intracellular neurofibrillary tangles (NFTs), granulovacuolar degeneration (GVD) representing cytoplasmic vacuolar lesions, synapse dysfunction and neuronal...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 139; no. 3; pp. 463 - 484
Main Authors:	Koper, Marta J., Van Schoor, Evelien, Ospitalieri, Simona, Vandenberghe, Rik, Vandenbulcke, Mathieu, von Arnim, Christine A. F., Tousseyn, Thomas, Balusu, Sriram, De Strooper, Bart, Thal, Dietmar Rudolf
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-03-2020 Springer Springer Nature B.V
Subjects:	Adolescent Adult Advertising executives Aged Aged, 80 and over Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid Brain Brain - metabolism Brain - pathology Cell death Cortex (frontal) Female Humans Kinases Lesions Male MAP kinase Medicine Medicine & Public Health Middle Aged Necroptosis Necroptosis - physiology Nerve Degeneration - metabolism Nerve Degeneration - pathology Neurodegeneration Neurodegenerative diseases Neurofibrillary tangles Neurons Neurons - pathology Neuropathology Neurophysiology Neurosciences Original Paper Pathology Physiological aspects Protein kinase Protein kinases Therapeutic applications Threonine Young Adult Granulovacuolar degeneration Necrosome Neuronal loss Alzheimer’s disease Necroptosis pMLKL
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