Adverse effects of maternal dioxin exposure on fetal brain development before birth assessed by neonatal electroencephalography (EEG) leading to poor neurodevelopment; a 2-year follow-up study

• Published in: The Science of the total environment Vol. 667; pp. 718 - 729
• Main Authors: Nghiem, GiangThi Thuy, Nishijo, Muneko, Pham, Thao Ngoc, Ito, Mika, Pham, Tai The, Tran, Anh Hai, Nishimaru, Hiroshi, Nishino, Yoshikazu, Nishijo, Hisao
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-06-2019
• Subjects: Dioxin; Fetal brain; Neonatal EEG; Neurodevelopment; Vietnam; TEQ; Vietnam; FFT; EEG; PCDD; Dioxin; TCDD; Neurodevelopment; Fetal brain; PCDD/Fs; Neonatal EEG
• ISSN: 0048-9697; 1879-1026
• DOI: 10.1016/j.scitotenv.2019.02.395

We previously reported the adverse effects of perinatal dioxin exposure on child neurodevelopment around a former US military airbase in Vietnam. In the present study, we investigated the effects of maternal dioxin exposure on fetal brain development, which may predict neurodevelopmental outcomes in early childhood. A total of 55 newborns with mothers from dioxin-contaminated areas were recruited in the prefecture hospital in Bien Hoa, Vietnam. Dioxins in maternal breast milk collected 1 month after birth were used as a maternal exposure marker. Relative powers and coherence were computed from neonatal electroencephalogram (EEG) records during active sleep stages. Relationships between the EEG parameters and dioxin exposure markers were analyzed using linear regression and a general linear model after adjusting for gestational age, body length, and head circumference of infants at birth. Using data from 47 infants whose neurodevelopment was examined in a 2-year follow-up study, associations between EEG parameters and neurodevelopment were analyzed after adjusting for confounding factors. On the right frontal and parietal regions, relative delta powers were significantly decreased, and relative alpha and beta powers were significantly increased with increasing dioxin exposure. Increases in delta power and decreases in alpha power on the right frontal and parietal regions were associated with an increase in language scores at 2 years of age. Furthermore, intra- and inter-hemispheric coherence in theta and alpha bands were positively and inversely correlated with dioxin exposure, respectively, and increased intra-coherence in the right hemisphere was associated with lower language scores. These findings suggest that prenatal dioxin exposure affects neuronal activity and functional connectivity between brain regions, and may lead to poor language development.
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•Prenatal dioxin exposure affects neuronal activity estimated from neonatal EEG.•Relative power and coherence of neonatal EEG are good markers for brain development.•Alteration of neonatal EEG might lead to poor language development at 2 years of age.