Acute Pancreatitis Causing Death in a Child on the Ketogenic Diet

The ketogenic diet has demonstrated good efficacy in children with pharmacologically resistant seizures. Relatively few serious complications have been reported in the more than 70 years in which the diet has been used. We report a child who developed acute pancreatitis and died. A 9-year-old girl h...

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Bibliographic Details
Published in:Journal of child neurology Vol. 16; no. 9; p. 682
Main Authors: Stewart, Wendy A., Gordon, Kevin, Camfield, Peter
Format: Journal Article
Language:English
Published: Thousand Oaks, CA Sage Publications 01-09-2001
SAGE PUBLICATIONS, INC
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Summary:The ketogenic diet has demonstrated good efficacy in children with pharmacologically resistant seizures. Relatively few serious complications have been reported in the more than 70 years in which the diet has been used. We report a child who developed acute pancreatitis and died. A 9-year-old girl had a seizure disorder with associated developmental delay owing to glucose transport protein deficiency. The ketogenic diet with medium chain triglyceride oil had been initiated shortly after diagnosis in infancy. She was not on anticonvulsants. She presented in coma with decreased respiratory effort and shock, requiring resuscitation. Investigations were consistent with pancreatitis. Despite fluid resuscitation and inotropic support, she had prolonged hypotension and acidosis. She subsequently had a cardiac arrest and died. A postmortem examination confirmed hemorrhagic pancreatitis. Hypertriglyceridemia is a risk factor for developing acute pancreatitis. The high fat content of the ketogenic diet often causes hyperlipidemia. The outcome for this patient raises concern regarding a potential consequence of the ketogenic diet. (J Child Neurol 2001;16:682).
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ISSN:0883-0738
1708-8283
DOI:10.1177/088307380101600910