Enhanced Antitumor Effect of Coincident Intravesical Gemcitabine Plus BCG Therapy in an Orthotopic Bladder Cancer Model

Objectives To evaluate the antitumor effect of the coincident administration of intravesical gemcitabine (Gem) plus bacillus Calmette-Guérin (BCG) in an orthotopic bladder cancer model. Methods We evaluated the cytotoxic effect of gemcitabine against MBT-2 cells in vitro. Orthotopic tumors were esta...

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Bibliographic Details
Published in:	Urology (Ridgewood, N.J.) Vol. 76; no. 5; pp. 1267.e1 - 1267.e6
Main Authors:	Horinaga, Minoru, Fukuyama, Ryuichi, Iida, Masahiro, Yanaihara, Hitoshi, Nakahira, Yoko, Nonaka, Shoichi, Deguchi, Nobuhiro, Asakura, Hirotaka
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2010
Subjects:	Adjuvants, Immunologic - administration & dosage Administration, Intravesical Animals Antimetabolites, Antineoplastic - administration & dosage BCG Vaccine - administration & dosage Cell Line, Tumor Deoxycytidine - administration & dosage Deoxycytidine - analogs & derivatives Dose-Response Relationship, Drug Female Ki-67 Antigen - analysis Mice Mice, Inbred C3H Neoplasm Transplantation Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Urology
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