Screening of Chiral Catalysts and Catalyst Mixtures by Mass Spectrometric Monitoring of Catalytic Intermediates
The enantioselectivity of chiral palladium catalysts in the kinetic resolution of allylic esters can be determined by mass spectrometric monitoring of allyl–Pd intermediates A and B, which are derived from pseudoenantiomeric substrates 1 a and 1 b. In contrast to conventional screening methods, whic...
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| Published in: | Angewandte Chemie International Edition Vol. 43; no. 19; pp. 2498 - 2500 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Weinheim
WILEY-VCH Verlag
03-05-2004
WILEY‐VCH Verlag |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | The enantioselectivity of chiral palladium catalysts in the kinetic resolution of allylic esters can be determined by mass spectrometric monitoring of allyl–Pd intermediates A and B, which are derived from pseudoenantiomeric substrates 1 a and 1 b. In contrast to conventional screening methods, which are based on product analysis, simultaneous screening of catalyst mixtures in homogeneous solution is possible. |
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| Bibliography: | istex:F3837EF5B39358C922789EE51E8960CE2CB94C36 We thank Solvias AG, Basel, for a free sample of their ligand kit. Financial support by the Swiss National Science Foundation is gratefully acknowledged. ark:/67375/WNG-BF0FQ34C-V ArticleID:ANIE200453844 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1433-7851 1521-3773 |
| DOI: | 10.1002/anie.200453844 |