Differential Susceptibility to Neurotoxicity Mediated by Neurotrophins and Neuronal Nitric Oxide Synthase

NMDA neurotoxicity, which is mediated, in part, by formation of nitric oxide (NO) via activation of neuronal NO synthase (nNOS), is modulated by neurotrophins. nNOS expression in rat and mouse primary neuronal cultures grown on a glial feeder layer is significantly less than that of neurons grown on...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 17; no. 12; pp. 4633 - 4641
Main Authors:	Samdani, Amer F, Newcamp, Cheryl, Resink, Annelies, Facchinetti, Fabrizio, Hoffman, Brian E, Dawson, Valina L, Dawson, Ted M
Format:	Journal Article
Language:	English
Published:	United States Soc Neuroscience 15-06-1997 Society for Neuroscience
Subjects:	Animals Arginine - pharmacology Brain-Derived Neurotrophic Factor - pharmacology Cell Survival - drug effects Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - embryology Coculture Techniques Embryo, Mammalian Fetus Gene Expression Regulation, Enzymologic - drug effects Glial Cell Line-Derived Neurotrophic Factor Kinetics Mice Mice, Inbred C57BL N-Methylaspartate - antagonists & inhibitors N-Methylaspartate - toxicity Nerve Growth Factors - pharmacology Nerve Tissue Proteins - pharmacology Neuroglia - physiology Neurons - cytology Neurons - drug effects Neurons - enzymology Neurotoxins Neurotrophin 3 NG-Nitroarginine Methyl Ester - pharmacology Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase - deficiency Nitric Oxide Synthase - metabolism Nitroprusside - pharmacology Peptides Rats Rats, Sprague-Dawley
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