Hsp90 Picks PIKKs via R2TP and Tel2

Phosphatidylinositol-3 kinase-like kinases (PIKKs) are dependent on Hsp90 for their activation via the R2TP complex and Tel2. In this issue of Structure, Pal and colleagues present the molecular mechanism by which PIKKs are recruited to Hsp90.

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Bibliographic Details
Published in:	Structure (London) Vol. 22; no. 6; pp. 799 - 800
Main Author:	Vaughan, Cara K.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 10-06-2014 Cell Press
Subjects:	Activation HSP90 Heat-Shock Proteins - chemistry HSP90 Heat-Shock Proteins - metabolism Kinases Molecular structure Nuclear Proteins - chemistry Nuclear Proteins - metabolism Picks Preview Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Telomere-Binding Proteins - chemistry Telomere-Binding Proteins - metabolism
Online Access:	Get full text
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Description
Summary:	Phosphatidylinositol-3 kinase-like kinases (PIKKs) are dependent on Hsp90 for their activation via the R2TP complex and Tel2. In this issue of Structure, Pal and colleagues present the molecular mechanism by which PIKKs are recruited to Hsp90.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 ObjectType-Feature-1
ISSN:	0969-2126 1878-4186
DOI:	10.1016/j.str.2014.05.012