Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy
Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. The frequency of subsequent fetomaternal microchimerism in healthy women and its cell type is unknown. To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied femal...
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| Published in: | The Lancet (British edition) Vol. 364; no. 9429; pp. 179 - 182 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
10-07-2004
Lancet Elsevier Limited |
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| Abstract | Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. The frequency of subsequent fetomaternal microchimerism in healthy women and its cell type is unknown. To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. Male cells were identified by XY fluorescence in-situ hybridisation in marrow-derived mesenchymal stem cells and in rib sections from all women with male pregnancies, but not in controls (9/9
vs 0/5, p=0·0005). We conclude that fetal stem cells transferred into maternal blood engraft in marrow, where they remain throughout life. This finding has implications for normal pregnancy, for obstetric complications that increase fetomaternal trafficking, and for graft survival after transplantation. |
|---|---|
| AbstractList | Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. The frequency of subsequent fetomaternal microchimerism in healthy women and its cell type is unknown. To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. Male cells were identified by XY fluorescence in-situ hybridisation in marrow-derived mesenchymal stem cells and in rib sections from all women with male pregnancies, but not in controls (9/9 vs 0/5, p=0.0005). We conclude that fetal stem cells transferred into maternal blood engraft in marrow, where they remain throughout life. This finding has implications for normal pregnancy, for obstetric complications that increase fetomaternal trafficking, and for graft survival after transplantation. Fetal cells enter maternal blood during pregnancy and persist in women with autoimmune disease. The frequency of subsequent fetomaternal microchimerism in healthy women and its cell type is unknown. To test the hypothesis that fetal mesenchymal stem cells persist in maternal organs, we studied female bone marrow and ribs. Male cells were identified by XY fluorescence in-situ hybridisation in marrow-derived mesenchymal stem cells and in rib sections from all women with male pregnancies, but not in controls (9/9 vs 0/5, p=0·0005). We conclude that fetal stem cells transferred into maternal blood engraft in marrow, where they remain throughout life. This finding has implications for normal pregnancy, for obstetric complications that increase fetomaternal trafficking, and for graft survival after transplantation. |
| Author | Kennea, Nigel O'Donoghue, Keelin Roberts, Irene AG Fisk, Nicholas M Chan, Jerry Anderson, Jonathan R de la Fuente, Josu Sandison, Ann |
| Author_xml | – sequence: 1 givenname: Keelin surname: O'Donoghue fullname: O'Donoghue, Keelin email: k.odonoghue@imperial.ac.uk organization: Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 2 givenname: Jerry surname: Chan fullname: Chan, Jerry organization: Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 3 givenname: Josu surname: de la Fuente fullname: de la Fuente, Josu organization: Department of Haematology, Division of Investigative Sciences Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 4 givenname: Nigel surname: Kennea fullname: Kennea, Nigel organization: Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 5 givenname: Ann surname: Sandison fullname: Sandison, Ann organization: Department of Histopathology, Charing Cross Hospital, London W6 8RF – sequence: 6 givenname: Jonathan R surname: Anderson fullname: Anderson, Jonathan R organization: Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 7 givenname: Irene AG surname: Roberts fullname: Roberts, Irene AG organization: Department of Haematology, Division of Investigative Sciences Imperial College London, Hammersmith Campus, London W12 0NN, UK – sequence: 8 givenname: Nicholas M surname: Fisk fullname: Fisk, Nicholas M organization: Institute of Reproductive and Developmental Biology, Division of Paediatrics, Obstetrics and Gynaecology Imperial College London, Hammersmith Campus, London W12 0NN, UK |
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| Cites_doi | 10.1002/art.501 10.1093/molehr/gag063 10.1097/00001703-200304000-00014 10.1016/S0140-6736(01)07099-4 10.1073/pnas.93.2.705 |
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| Keywords | Human Pregnancy Medicine Microchimerism Fetal cell Bone marrow Female Mesenchymal cell Woman Cell migration |
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| References | Khosrotehrani, Bianchi (bib5) 2003; 15 Nelson (bib1) 2002; 46 Srivatsa, Srivatsa, Johnson, Samura, Lee, Bianchi (bib3) 2001; 358 Bianchi, Zickwolf, Weil, Sylvester, DeMaria (bib2) 1996; 93 O'Donoghue, Choolani, Chan, de la Fuente, Kumar, Campagnoli, Bennett, Roberts, Fisk (bib4) 2003; 9 15567005 - Lancet. 2004 Nov 27-Dec 3;364(9449):1936 Srivatsa (10.1016/S0140-6736(04)16631-2_bib3) 2001; 358 Khosrotehrani (10.1016/S0140-6736(04)16631-2_bib5) 2003; 15 Bianchi (10.1016/S0140-6736(04)16631-2_bib2) 1996; 93 O'Donoghue (10.1016/S0140-6736(04)16631-2_bib4) 2003; 9 Nelson (10.1016/S0140-6736(04)16631-2_bib1) 2002; 46 |
| References_xml | – volume: 9 start-page: 497 year: 2003 end-page: 502 ident: bib4 article-title: Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis publication-title: Mol Hum Reprod contributor: fullname: Fisk – volume: 46 start-page: 291 year: 2002 end-page: 297 ident: bib1 article-title: Pregnancy and Microchimerism in Autoimmune Disease: Protector or Insurgent? publication-title: Arthritis Rheum contributor: fullname: Nelson – volume: 15 start-page: 195 year: 2003 end-page: 199 ident: bib5 article-title: Fetal cell microchimerism: helpful or harmful to the parous woman? publication-title: Curr Opin Obstet Gynecol contributor: fullname: Bianchi – volume: 93 start-page: 705 year: 1996 end-page: 708 ident: bib2 article-title: Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum publication-title: Proc Natl Acad Sci USA contributor: fullname: DeMaria – volume: 358 start-page: 2034 year: 2001 end-page: 2038 ident: bib3 article-title: Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study publication-title: Lancet contributor: fullname: Bianchi – volume: 46 start-page: 291 year: 2002 ident: 10.1016/S0140-6736(04)16631-2_bib1 article-title: Pregnancy and Microchimerism in Autoimmune Disease: Protector or Insurgent? publication-title: Arthritis Rheum doi: 10.1002/art.501 contributor: fullname: Nelson – volume: 9 start-page: 497 year: 2003 ident: 10.1016/S0140-6736(04)16631-2_bib4 article-title: Identification of fetal mesenchymal stem cells in maternal blood: implications for non-invasive prenatal diagnosis publication-title: Mol Hum Reprod doi: 10.1093/molehr/gag063 contributor: fullname: O'Donoghue – volume: 15 start-page: 195 year: 2003 ident: 10.1016/S0140-6736(04)16631-2_bib5 article-title: Fetal cell microchimerism: helpful or harmful to the parous woman? publication-title: Curr Opin Obstet Gynecol doi: 10.1097/00001703-200304000-00014 contributor: fullname: Khosrotehrani – volume: 358 start-page: 2034 year: 2001 ident: 10.1016/S0140-6736(04)16631-2_bib3 article-title: Microchimerism of presumed fetal origin in thyroid specimens from women: a case-control study publication-title: Lancet doi: 10.1016/S0140-6736(01)07099-4 contributor: fullname: Srivatsa – volume: 93 start-page: 705 year: 1996 ident: 10.1016/S0140-6736(04)16631-2_bib2 article-title: Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.93.2.705 contributor: fullname: Bianchi |
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| SubjectTerms | Aged Aged, 80 and over Autoimmune diseases Biological and medical sciences Blood Bone and Bones - cytology Bone marrow Bone Marrow Cells - cytology Chimera Chromosomes Chromosomes, Human, X Chromosomes, Human, Y Female Females Fetus - cytology Fetuses General aspects Humans In Situ Hybridization, Fluorescence Male Maternal-Fetal Exchange Medical sciences Mesoderm - cytology Middle Aged Oils & fats Pregnancy Ribs Selective media Stem cells Stem Cells - cytology Time Factors |
| Title | Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy |
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