Extent of resection in the management of duodenal adenocarcinoma

• Published in: The American journal of surgery Vol. 179; no. 1; pp. 37 - 41
• Main Authors: Kaklamanos, Ioannis G, Bathe, Oliver F, Franceschi, Dido, Camarda, Christina, Levi, Joe, Livingstone, Alan S
• Format: Journal Article Conference Proceeding
• Language: English
• Published: New York, NY Elsevier Inc 01-01-2000; Elsevier; Elsevier Limited
• Subjects: Actuarial Analysis; Adenocarcinoma; Adenocarcinoma - mortality; Adenocarcinoma - surgery; Biological and medical sciences; Duodenal Neoplasms - mortality; Duodenal Neoplasms - surgery; Duodenum; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Lymph Node Excision; Lymph nodes; Lymphatic system; Male; Medical prognosis; Medical sciences; Metastasis; Middle Aged; Morbidity; Multivariate analysis; Pancreaticoduodenectomy; Patients; Proportional Hazards Models; Stomach, duodenum, intestine, rectum, anus; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Survival; Survival Analysis; Tumors; Adenocarcinoma; Human; Prognosis; Duodenal disease; Duodenum; Surgical resection; Malignant tumor; Survival; Result; Extension; Treatment; Segmental; Surgery; Digestive diseases; Intestinal disease; Technique; Pancreas; Comparative study; Bibliographic review; Pancreatoduodenectomy
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/S0002-9610(99)00269-X

Background: It has been postulated that segmental duodenal resection (SR) is not an adequate operation for patients with adenocarcinoma of the duodenum and that pancreaticoduodenectomy (PD) is the procedure of choice, regardless of the tumor site. However, data from previous studies do not clearly support this position.
Methods: We reviewed the records of 63 patients treated for duodenal adenocarcinoma from 1979 through 1998. Perioperative outcome, patient survival, and extent of lymphadenectomy were compared in patients who underwent PD and SR.
Results: The overall morbidity for PD and SR was 27% and 18%, respectively (not significant [NS]). Patients who underwent SR had a 5-year survival of 60% versus 30% for patients who underwent PD (NS). Lymph node status was a prognostic factor for survival (P = 0.014). The mean number of lymph nodes in the specimens was 9.9 ± 2.1 for PD and 8.3 ± 4.4 for SR (NS).
Conclusions: Segmental duodenal resection for patients with duodenal adenocarcinoma is associated with acceptable postoperative morbidity and long-term survival. The procedure is especially well suited for distal duodenal tumors. Clearance of lymph nodes and outcome are comparable to PD.