Synthesis and antioxidant activity of new C-3 sulfenyl indoles

A convenient and efficient methodology for the synthesis of new C-3 sulfur-substituted indoles under CeCl3·7H2O promotion is reported. Model bis(indol-3-yl)sulfide 4a and bis(indol-3-yl)sulfone 5a proved to display potent antioxidant activity at the low micromolar level, in DPPH, ABTS, and FRAP assa...

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Bibliographic Details
Published in:	Tetrahedron letters Vol. 54; no. 36; pp. 4926 - 4929
Main Authors:	Silveira, Claudio C., Mendes, Samuel R., Soares, Josemar R., Victoria, Francine N., Martinez, Débora M., Savegnago, Lucielli
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-09-2013
Subjects:	Antioxidant activity Antioxidants Assaying Cerium(III) chloride heptahydrate Indole sulfide derivatives Indoles Inhibition Level (quantity) Microwave-assisted synthesis Promotion Synthesis (chemistry) Tetrahedrons Indole sulfide derivatives Cerium(III) chloride heptahydrate Antioxidant activity Microwave-assisted synthesis
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Summary:	A convenient and efficient methodology for the synthesis of new C-3 sulfur-substituted indoles under CeCl3·7H2O promotion is reported. Model bis(indol-3-yl)sulfide 4a and bis(indol-3-yl)sulfone 5a proved to display potent antioxidant activity at the low micromolar level, in DPPH, ABTS, and FRAP assays, as well as in the inhibition of the peroxidation of linoleic acid.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0040-4039 1873-3581
DOI:	10.1016/j.tetlet.2013.07.004