An Immortalization -Dependent Switch in Integrin Function Up-regulates MMP-9 to Enhance Tumor Cell Invasion

Integrins, the major receptors for cell adhesion to the extracellular matrix, play important roles during tumor progression. However, it is still unclear whether genetic lesions that occur during carcinoma development can lead to altered integrin function, and how changes in integrin function contri...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 68; no. 18; pp. 7371 - 7379
Main Authors:	LAMAR, John M, PUMIGLIA, Kevin M, DIPERSIO, C. Michael
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-09-2008
Subjects:	Animals Antineoplastic agents Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Line, Transformed Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Cells, Cultured Gene Expression Humans Integrin alpha3beta1 - metabolism Keratinocytes - enzymology Keratinocytes - metabolism Keratinocytes - pathology Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Medical sciences Mice Mice, Nude Neoplasm Invasiveness Pharmacology. Drug treatments RNA, Messenger - biosynthesis RNA, Messenger - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors Up-Regulation Enzyme Cell adhesion molecule Metalloendopeptidases Malignant tumor Cell immortalization Metastasis Gelatinase B Invasion Peptidases Integrin Hydrolases Tumor cell Cancer
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