Trichogin GA IV Alignment and Oligomerization in Phospholipid Bilayers

Trichogin GA IV is a short peptaibol with antimicrobial activity. This uncharged, but amphipathic, sequence is aligned at the membrane interface and undergoes a transition to an aggregated state that inserts more deeply into the membrane, an assembly that predominates at a peptide‐to‐lipid ratio (P/...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 20; no. 16; pp. 2141 - 2150
Main Authors:	Salnikov, Evgeniy S., De Zotti, Marta, Bobone, Sara, Mazzuca, Claudia, Raya, Jesus, Siano, Alvaro S., Peggion, Cristina, Toniolo, Claudio, Stella, Lorenzo, Bechinger, Burkhard
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 16-08-2019 Wiley-VCH Verlag
Series:	10th IPS
Subjects:	Alignment Antimicrobial activity Antimicrobial agents antimicrobial peptides ATR FTIR spectroscopy Chemical equilibrium Chemical Sciences Helices Inserts Lipid bilayers Lipids Medicinal Chemistry membrane permeabilization NMR Nuclear magnetic resonance Oligomerization Organic chemistry Peptides Phospholipids solid-state NMR spectroscopy Topology Trichogin membrane permeabilization lipid bilayers solid-state NMR spectroscopy ATR FTIR spectroscopy antimicrobial peptides
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