CXC chemokines in angiogenesis

• Published in: Journal of leukocyte biology Vol. 68; no. 1; pp. 1 - 8
• Main Authors: Belperio, John A., Keane, Michael P., Arenberg, Douglas A., Addison, Christina L., Ehlert, Jan E., Burdick, Marie D., Strieter, Robert M.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01-07-2000
• Subjects: Amino Acid Motifs; Angiogenesis Inhibitors - pharmacology; Animals; Arthritis, Rheumatoid - physiopathology; Chemokine CXCL10; Chemokines, CXC - chemistry; Chemokines, CXC - classification; Chemokines, CXC - physiology; Chronic Disease; cytokines; Fibrosis; Humans; Inflammation; Interleukin-8 - physiology; Mice; Mice, Nude; Neoplasm Proteins - physiology; Neoplasms - blood supply; neovascularization; Neovascularization, Pathologic - physiopathology; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - physiology; Pulmonary Fibrosis - physiopathology; Receptors, Chemokine - physiology; Structure-Activity Relationship; tumor metastasis; tumorigenesis; wound repair
• ISSN: 0741-5400; 1938-3673
• DOI: 10.1189/jlb.68.1.1

A variety of factors have been identified that regulate angiogenesis, including the CXC chemokine family. The CXC chemokines are a unique family of cytokines for their ability to behave in a disparate manner in the regulation of angiogenesis. CXC chemokines have four highly conserved cysteine amino acid residues, with the first two cysteine amino acid residues separated by one non‐conserved amino acid residue (i.e., CXC). A second structural domain within this family determines their angiogenic potential. The NH2 terminus of the majority of the CXC chemokines contains three amino acid residues (Glu‐Leu‐Arg: the ELR motif), which precedes the first cysteine amino acid residue of the primary structure of these cytokines. Members that contain the ELR motif (ELR+) are potent promoters of angiogenesis. In contrast, members that are inducible by interferons and lack the ELR motif (ELR−) are potent inhibitors of angiogenesis. This difference in angiogenic activity may impact on the pathogenesis of a variety of disorders.